ISSN: 1859 - 2872
Assessing the effectiveness of treating genital lichen sclerosus by combining topical corticosteroids with tacrolimus
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Keywords
Treatment lichen sclerosus, genital lichen sclerosus
Abstract
Objective: To assess the effectiveness of treating genital lichen sclerosus by combining topical corticosteroids with tacrolimus. Subject and method: Clinical trial compared the effectiveness before and after treatment. Result: In the total of 37 treated patient, we saw 5.4% were mild, 67.6% were moderate, 27.0% were severe. After 1 month, no symptoms were seen in 73% of patients. Moreover, the mean effectiveness was 44.11% and 53.32% in 3 months and 6 months, respectively. The itching and burning symptoms improved rapidly. Conclusion: The treatment of genital lichen sclerosus by corticosteroids in the first month and tacrolimus in the next 5 months showed the effectiveness was 55.32%.
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References
1. Hallopeau H (1987) Du lichen plan et particulièrement de sa forme atrophique: Lichen plan scléreux. Ann. Dermatol. Syphiligr 8: 790-791.
2. Friedrich EG (1976) Lichen sclerosus. J. Reprod Med 17: 147-154.
3. Wallace HJ (1971) Lichen sclerosus et atrophicus. Trans. St. Johns. Hosp. Dermatol. Soc 57(1): 9-30.
4. Neill SM, Lewis FM, Tatnall FM et al (2010) British Association of Dermatologists’ guidelines for the management of lichen sclerosus 2010. Br J Dermatol 163: 672-682.
5. Kunstfeld, Rainer et al (2003) Successful treatment of vulvar lichen sclerosus with topical tacrolimus. Archives of dermatology 139(7): 850-852.
6. Hengge, Ulrich R et al (2006) Multicentre, phase II trial on the safety and efficacy of topical tacrolimus ointment for the treatment of lichen sclerosus. British Journal of Dermatology 155(5): 1021-1028.
7. Günthert AR, Duclos K, Jahns BG, Krause E, Amann E, Limacher A et al (2012) Clinical scoring system for vulvar lichen sclerosus. J Sex Med 9: 2342-2350.
8. Howard, Matthew, and Anthony Hall (2018) Treatment of penile lichen sclerosus with topical corticosteroids for over 25 years’ duration: A case report. SAGE open medical case reports 6: 2050313X18795047.
9. Garzon, Maria C, and Amy S Paller (1999) Ultrapotent topical corticosteroid treatment of childhood genital lichen sclerosus. Archives of dermatology 135(5): 525-528.
10. Virgili A, Lauriola MM, Mantovani L et al (2007) Vulvar lichen sclerosus: 11 women treated with tacrolimus 0.1% ointment. Acta Derm Venereol 87: 69-72.
2. Friedrich EG (1976) Lichen sclerosus. J. Reprod Med 17: 147-154.
3. Wallace HJ (1971) Lichen sclerosus et atrophicus. Trans. St. Johns. Hosp. Dermatol. Soc 57(1): 9-30.
4. Neill SM, Lewis FM, Tatnall FM et al (2010) British Association of Dermatologists’ guidelines for the management of lichen sclerosus 2010. Br J Dermatol 163: 672-682.
5. Kunstfeld, Rainer et al (2003) Successful treatment of vulvar lichen sclerosus with topical tacrolimus. Archives of dermatology 139(7): 850-852.
6. Hengge, Ulrich R et al (2006) Multicentre, phase II trial on the safety and efficacy of topical tacrolimus ointment for the treatment of lichen sclerosus. British Journal of Dermatology 155(5): 1021-1028.
7. Günthert AR, Duclos K, Jahns BG, Krause E, Amann E, Limacher A et al (2012) Clinical scoring system for vulvar lichen sclerosus. J Sex Med 9: 2342-2350.
8. Howard, Matthew, and Anthony Hall (2018) Treatment of penile lichen sclerosus with topical corticosteroids for over 25 years’ duration: A case report. SAGE open medical case reports 6: 2050313X18795047.
9. Garzon, Maria C, and Amy S Paller (1999) Ultrapotent topical corticosteroid treatment of childhood genital lichen sclerosus. Archives of dermatology 135(5): 525-528.
10. Virgili A, Lauriola MM, Mantovani L et al (2007) Vulvar lichen sclerosus: 11 women treated with tacrolimus 0.1% ointment. Acta Derm Venereol 87: 69-72.
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How to Cite
Hoang ThiH., & Pham ThiL. (2019). Assessing the effectiveness of treating genital lichen sclerosus by combining topical corticosteroids with tacrolimus. Tạp Chí Y Dược lâm sàng 108, 14(7). Retrieved from https://tcydls108.benhvien108.vn/index.php/YDLS/article/view/34