Mối liên quan giữa SOD, GPx, MDA và trạng thái chống oxy hóa toàn phần với đặc điểm mô bệnh học ở bệnh nhân viêm dạ dày mạn

Abstract

Objective: To study the relation of serum SOD, GPx, MDA concentration and TAS with histopathological characteristics in patients with chronic gastritis. Subject and method: A descriptive, cross-sectional study was conduted on 136 patient with chronic gastritis. Result: SOD activity in the group with atrophic inflammation 348.54 ± 458.19ng/ml was lower than the group without atrophic inflammation 406.95 ± 309.61ng/ml (p=0.04). SOD activity in the inflammatory group was active highest at 326.27 ± 450.79ng/ml, lower than the active inflammatory group with a mild level of 449.09 ± 481.27ng/ml (p=0.03). GPx activity in the group with atrophic inflammation was 182.71 ± 223.58pg/ml, lower than the group without atrophic inflammation 209.98 ± 159.53pg/ml (p=0.005). GPx activity in the group with dysplasia 94.2 ± 84.23pg/ml was lower than the group without dysplasia 199.97 ± 222.37pg/ml (p=0.03). TAS activity was lowest in the group of severe inflammation and highest in mild inflammation group (p=0.03). TAS activity in the group with atrophic inflammation was 2.02 ± 3.48U/ml higher than the group without atrophic 1.12 ± 1.46U/ml (p=0.002). MDA activity in the group with atrophic inflammation was 5.19 ± 6.84mmol/l lower than the group without inflammation at 7.19 ± 4.96mmol/l (p=0.006). MDA activity in the active inflammation group was low at 7.42 ± 8.34mmol/l, higher than the inflammatory group at the severity of 4.64 ± 5.22mmol/l (p=0.04). Conclusion: The activity of antioxidants in plasma is the lowest in cases of atrophic inflammation, at the same time the activity of antioxidants decreases with the degree of inflammation activity.