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Objective: Recorded changes in hemoglobin, hematocrite, blood pressure, blood sodium and blood gas before and after 120 minutes in patients with severe brain injury using hypertonic saline 7.5% and mannitol for the reduction of intracranial pressure. Subject and method: Case study of controlled clinical trials of 100 patients severe traumatic brain injury with increase intracranial pressure treated at surgical resuscitation of Sait Paul Hospital from October 2010 to December 2014. Result: After treatment hypertonic saline 7.5% and mannitol 20%, hemoglobin, hematocrite both decreased, but both in normal limits, no difference between the two treatment groups. There was no difference in blood gas changes between the two treatment groups after infusion of osmotic fluid. Compared with mannitol 20% group, the blood osmotic pressure and blood sodium in the hypersonic saline 7.5% group increased after 120 min (p<0.05). Conclusion: Hypertonic saline 7.5% and mannitol change hemoglobin, hematocrite, blood osmotic pressure and blood gas, but these changes do not affect the reduction treatment.