ISSN: 1859 - 2872
Determining the concentration and relationship of some cytokine with clinical characteristics of pustular psoriasis
Main Article Content
Keywords
Abstract
Objective: To determine the concentration and relationship of some cytokines (IL-2, IL-4, IL-6, IL-10, IL-17, TNF-α, INF-γ) with the clinical characteristics of pustular psoriasis. Subject and method: A cross-sectional description on 30 patients with pustular psoriasis treated at the National Hospital of Dermatology and Venereology and Department of Dermatology and Allergy, 108 Military Central Hospital. Result: Cytokines IL-2, IL-10, and IL-17 were higher in generalized pustular psoriasis patients than in healthy people, IL-6 in pustular psoriasis patients with no history of psoriasis was higher than a group of patients with a history of psoriasis vulgaris and gradually increased with severity. IL-8 increased inversely with disease severity. Conclusion: There was a change of IL-2, 6, 8, 10, 17 in pustular psoriasis patients.
Keywords: Pustular psoriasis, cytokine, IL-2, IL-4, IL-6, IL-10, IL-17, TNF-α, INF-γ.
Article Details
References
2. Thục PH (2014) Nghiên cứu đặc điểm lâm sàng và mối liên quan giữa nồng độ cytokine với kết quả điều trị bệnh vảy nến thông thường bằng methotrexate. Luận văn Tiến sĩ, Trường Đại học Y Hà Nội.
3. Toruniowa B, Kozio M, and Pietrzak A (2006) Serum levels of IL-6 in mycosis fungoides, psoriasis, and lichen planus. Annals new york academy of sciences: 432-434.
4. Ohkawara AYH, Kobayashi H, Inaba Y, Ogawa H, Hashimoto I, Imamura S (1996) Generalized pustular psoriasis in Japan: Two distinct groups formed by differences in symptoms and genetic background. Acta Derm Venereol 76(1): 68-71.
5. Peter Neuner A, Franz Trautinger, Annelie Möller, Reinhard Kirnbauer, Alexander Kapp, Erwin Schöpf, Thomas Schwarz, Thomas Aluger (1991) Increased IL-6 production by monocytes and keratinocytes in patients with psoriasis. Journal of Investigative Dermatology 97(1): 27-33.
6. Andrew Johnston P (2017) IL-1 and IL-36 are dominant cytokines in generalized pustular psoriasis. J allergy clin immunol 140(1): 109-120.
7. Robert Bissonnette CWL, James GK, Jerry T, Nigen S, Innovaderm R, Montreal, Quebec, Canada; Richart BL. Interleukins -23 and -17 in patients with palmoplantar pustular psoriasis and palmoplantar pustulosis. J am acad dermatol: 201.
8. Takahashi H, Hashimoto Y, Ishida-Yamamoto A and Iizuka H (2010) Serum cytokines and growth factor levels in Japanese patients with psoriasis. Clinical and Experimen.
9. Capon F (2013) IL36RN mutations in generalized pustular psoriasis: Just the tip of the iceberg. J Invest Dermatol 133: 2503-2504.
10. Klau Wolff LA, Goldsmith Stephan I, Katz, Barbara A, Gilchrest Amy S, David J, Leffell (2009) Fitzpatrick’s Dermatology in general medicine sixth edition: 169-210.
11. Takahashi H, Nakamura K, Kaneko F et al (2011) Analysis of psoriasis patients registered with the Japanese Society for Psoriasis Research from 2002-2008. J Dermatol 38: 1125-1129.
12. Yamamoto M, Imai Y, Sakaguchi Y, Haneda T, Yamanishi K (2013) Serum cytokines correlated with the disease severity of generalized pustular psoriasis. Dis Markers 34(3): 153-161.
13. Owczarczyk-Saczonek A, Czerwińska J, Orylska M, Placek W (2019) Evaluation of selected mechanisms of immune tolerance in psoriasis. Advances in Dermatology and Allergology 36(3): 315-324.
14. Borska L, Krejsek J et al (2008) Serum levels of the proinflammatory cytokine interleukin-12 and the anti-inflammatory cytokine interleukin-10 in patients with psoriasis treated by the Goeckerman regimen. Int J Dermatol 47: 800-805.
Article Sidebar
