Đặc điểm lâm sàng, cận lâm sàng và tính kháng kháng sinh ở bệnh nhân nhiễm khuẩn huyết do Staphylococcus aureus điều trị tại Bệnh viện Trung ương Quân đội 108 từ năm 2016 đến năm 2018

Abstract

Objective: To study clinical, subclinical characteristics and antibiotic resistance in sepsis patients caused by S. aureus at 108 Military Central Hospital. Subject and method: 57 sepsis patients according to Sepsis-2 and having blood culture positive with S. aureus were recruited into this study. Result: Most patients were old age (64.9%), male (64.9%). The isolation of S. aureus originated from hospital (47.4%). The proportion of septic shock and death were 35.1%, 47.4%, respectively. Common medical comorbidities: Diabetes (42.1%), hypertension (31.6%), chronic lung diseases (29.8%). The most common primary infection was respiratory tract (43.9%), followed by skin-soft tissue (35.1%). Leukocytosis was 73.7% and 70.2% of patients had PCT > 10ng/ml. The rate of MRSA was 47.4%. The strains of S. aureus were quite sensitive to quinolon. 100% of strains were sensitive to vancomycin. The level of resistance in MRSA group was higher than that of MSSA groups, significant difference with moxifloxacin, levofloxacin, erythromycin and tetracycline. Conclusion: Sepsis caused by S. aureus had a high rate of shock and death. Nearly 50% of the isolates were MRSA.