ISSN: 1859 - 2872
The relationship between ARFI index, liver enzyme levels and etiologies in fatty liver patients
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Abstract
Objective: To evaluate the relationship between liver tissue stiffness with liver enzyme levels and hepatitis etiologies in patients with fatty liver. Subject and method: A cross-sectional descriptive study was conducted at the Institue of Gastroenterology and Hepatology from January 2019 to August 2020 among patients who were ≥ 18 years old diagnosed with fatty liver on ultrasound, and measured shear wave velocity (SWV) on ARFI elastography. ARFI measurement was performed in segment V and VIII, final results were calculated as average values. Laboratory tests including liver enzymes, lipid profile were investigated. Result: 100 patients were eligible (78% males), the mean age was 46.19 ± 12.22 years. The severity of fatty liver with grade I, II and III were 65, 34, and 1 patient, respectively. The mean SWV was 1.26 ± 0.28m/s. SWV value was significantly higher in males and in segment VIII, but not different among fatty liver grades. SWV had a positive correlation with liver enzymes (AST, ALT, GGT), and cholesterol, triglyceride levels. The mean SWV was significantly different between levels of liver enzymes elevation, but similar among patients with different hepatitis etiologies. Conclusion: Liver tissue stiffness was different between levels of liver enzymes elevation, but similar among etiological groups of fatty liver.
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