The role of microRNAs as potential biomarkers in the prognosis of shock in septic patients treated at the 108 Military Central Hospital and Viet Tiep Hospital from 2014 to 2017

  • Tran Thi Lien 108 Military Central Hospital
  • Ngo Tat Trung 108 Military Central Hospital
  • Vu Viet Sang 108 Military Central Hospital
  • Le Huu Song 108 Military Central Hospital

Main Article Content

Keywords

Sepsis, septic shock, microRNA-146-3p, microRNA-147b, microRNA-155, microRNA-223

Abstract

Summary


Objective: In this study, we aimed to investigate the significance of circulating microRNAs (microRNA-155, microRNA-147b, microRNA-223, microRNA-146-3p) in the prognosis of sepsis. Subject and method: 71 sepstic patients at 108 Military Central Hospital & Viet Tiep Hospital from November 2014 to July 2017 were enrolled. The expression of microRNA-146-3p, microRNA-147b, microRNA-155, microRNA-223 were measured by q-RT-PCR in the Department of Molecular Biology at 108 Military Central Hospital. The ROC used to shock in prognosis in septic patients. Result and conclusion: The expression level of 4 microRNAs: MicroRNA-146-3p, microRNA-147b, microRNA-155, microRNA-223 in septic shock patients group was higher than in septic patients group (p<0.05). The expression level of 4 microRNAs was also higher in the group without organ failure with p<0.05. The prognosis value of septic shock of 3 microRNAs (microRNA-146-3p, microRNA-147b, microRNA-223) was quite good, with AUC > 0.7.


Keywords: Sepsis, septic shock, microRNA 146-3p, microRNA-147b, microRNA-155, microRNA-223.

Article Details

References

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Published
Aug 26, 2020
Issue
Volume 15 - No 8/2020
Section
Articles
How to Cite
Thi LienT., Tat TrungN., Viet SangV., & Huu SongL. (2020). The role of microRNAs as potential biomarkers in the prognosis of shock in septic patients treated at the 108 Military Central Hospital and Viet Tiep Hospital from 2014 to 2017. Tạp Chí Y Dược lâm sàng 108, 15(8). Retrieved from https://tcydls108.benhvien108.vn/index.php/YDLS/article/view/695