ISSN: 1859 - 2872
Relationship between serum alpha fetoprotein with tumor characteristics and stage in patients with HBV-associated hepatocellular carcinoma
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Abstract
Objective: To determine the relationship between serum alpha fetoprotein (AFP) with some tumor characteristics and stage in patients with hepatitis B virus (HBV) - associated hepatocellular carcinoma (HCC). Subject and method: The prospective, cross-sectional descriptive study carried out on 180 patients with HCC with HBsAg (+) in Digestive Department of 103 Military Hospital. Serum AFP concentration was determined by chemiluminescence immunoassay. Tumor characteristics was diagnosed on imaging studies. Result: In patients with HBV-associated HCC, the increase in serum AFP above 20ng/mL accounted for 65.5%, intermediate stage (60.0%), tumor size over 5cm (79.8%), nodular and massive form (66.1%) and portal vein thrombose (19.4%). Serum AFP concentration was increased parallelly with tumor size and BCLC stage. Conclusion: There is the significant relationship between serum AFP with tumor size and Barcelona staging classification for HCC.
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References
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