ISSN: 1859 - 2872
Hepatocellular carcinoma after radio frequency with Cool-tip electrode: Long term survival and prognostic factors
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Abstract
Subjective: To evaluate long term survival and predictive factors of percutaneous Radiofrequency Ablation with Cool-tip for the treatment of hepatocellular carcinoma (HCC). Subject and method: A prospective study involved 82 cirrhotic HCC patients (mean tumor size: 31.54 ± 10.7mm) underwent percutaneous RFA using Cool-tip RF electrode (COOL-TIP E SERRIES, COVIDIEN) at the 108 Military Central Hospital, from September 2012 to July 2020). The Kaplan-Meier curves and the multivariate Cox regression analysis were used to assess long term survival and the prognostic factors. Result: The 3 year, 4 year, 5 year, 6 year, 7 year cumulative survival rate were 90.2%, 84.1%, 37.8%, 34.1% and 18.3% respectively. Tumour free survival 3 year, 4 year, 5 year, 6 year were 64.6%, 35.3%, 8.5% and 2.4%. At multivariate analysis, independent prognostic factors for survival rate are tumour size, number of tumour, Child-Pugh classification meanwhile number of tumour and AFP response were the predictive factors for progression free survival. Conclusion: RFA with Cool-tip electrode is effective and result in long term survirval, especially for patients with a single tumor, tumour size < 3cm, and well-preserved liver function.
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References
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