ISSN: 1859 - 2872
Diagnostic value of plasma mRNA VEGF in identifying non-small cell lung cancer
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Abstract
Summary
Objective: This study aims to investigate the expression of VEGF mRNA in patients with non-small cell lung cancer in order to accurately diagnose the disease at an earlier stage. Subject and method: One hundred patients with non-small cell lung cancer (NSCLC) and 51 healthy subjects participated in this cross-sectional study. Relative expression of VEGF mRNA in plasma samples was assessed by realtime PCR. Result: The relative expression mRNA of the VEGF gene in patient group was significantly higher compared to that in the control group (p=0.007). The expression of plasma VEGF mRNA was capable to distinguish the patients with NSCLC from control individuals with the AUC value was 0.615 (p=0.028). Conclusion: The expression of VEGF mRNA in plasma maybe a potential biomarker that contributes to diagnosis of the disease.
Keywords: Lung cancer, non-small cell lung cancer, VEGF.
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References
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