ISSN: 1859 - 2872
Preliminary results of autologous bone-marrow stem cell transplantation for treatment of decompensated liver cirrhosis due to chronic Hepatitis B infection
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Abstract
Objective: To evaluate the feasibility and efficacy of autologous bone-marrow stem cell transplantation for treatment of decompensated liver cirrhosis patients due to chronic hepatitis B, Child B stage. Subject and method: 18 decompensated liver cirrhosis patients (pts) due to hepatitis B virus (age from 40 to 72) with Child-Pugh B were enrolled in the present study from June 2016 to December 2017. Bone-marrow hepatopoietic stem cells (BM-HSC) were collected from 200 - 300ml of bone-marrow fluid and injected into the liver through hepatic artery. The patiens were followed up at 1, 3, and 6 months after transplantation. Result: There was a significant improvement in clinical profile containing quality of life index, jaundice and ascites. No severe complication was observed in those pts during follow up. Albumin level was significantly increase after BM-HSC transplantation in comparation with before treatment with p<0.05. After 6 months prothrombin level (T6) was significantly higher than before treatment (T0) with values 71.00 ± 13.59 and 62.17 ± 14.84, respectively. Serum total bilirubin after treatment was slightly lower than before treatment, but it was not significant. Conclusion: Liver function significantly improved in decompensated liver cirrhosis patients after treatment with autologous bone-marrow stem cells through hepatic artery and no severe complication was observed relating to stem cell transplantation.
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2. Dương Đình Toàn, L.T.K (2014) Kết quả bước đầu điều trị thoái hóa khớp gối bằng nội soi tái tạo tổn thương dưới sụn và ghép khối tế bào gốc tủy xương tự thân. Tạp chí Y - Dược học Quân sự, tr. 7.
3. Gilchrist ES and JN Plevris (2010) Bone marrow-derived stem cells in liver repair: 10 years down the line. Liver Transpl 16(2): 118-129.
4. Am Esch JS et al (2005) Portal application of autologous CD133+ bone marrow cells to the liver: A novel concept to support hepatic regeneration. Stem Cells 23(4): 463-470.
5. Bai YQ et al (2014) Outcomes of autologous bone marrow mononuclear cell transplantation in decompensated liver cirrhosis. World J Gastroenterol 20(26): 8660-2666.
6. Peng L et al (2011) Autologous bone marrow mesenchymal stem cell transplantation in liver failure patients caused by hepatitis B: short-term and long-term outcomes. Hepatology 54(3): 820-828.
7. Kim JK et al (2010) Autologous bone marrow infusion activates the progenitor cell compartment in patients with advanced liver cirrhosis. Cell Transplant 19(10): 1237-1246.
8. Saito T et al (2011) Potential therapeutic application of intravenous autologous bone marrow infusion in patients with alcoholic liver cirrhosis. Stem Cells Dev 20(9): 1503-1510.
9. Lyra AC et al (2007) Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease. World J Gastroenterol 13(7): 1067-1073.
10. Lyra AC et al (2010) Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: A pilot randomized controlled study. Eur J Gastroenterol Hepatol 22(1): 33-42.
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