Đánh giá mối liên quan giữa đề kháng insulin với một số yếu tố nguy cơ tim mạch ở bệnh nhân tăng huyết áp nguyên phát

Abstract

Objective: Evaluating the association between insulin resistance and some cardiovascular risk factors in patients with primary hypertension. Subject and method: A cross-sectional and case- control study was carried out on 136 patients with primary hypertension. 30 healthy volunteers with the same distribution of age, body mass index, and gender were used for control. Diagnosis of hypertension was based on the JNC VII 2003 criteria. Diagnosis of insulin resistance was based on HOMA2-IR index according to HOMA2 computer model updated in 2007. Cardiovascular risk factors included age, body mass index, central obesity, physical activity, smoking, dyslipidemia, family history of hypertension and diabetes. The study period was from January 2017 to January 2018 at 121 Military Hospital. Result: Insulin resistance rates in patients with primary hypertension were significantly higher than healthy control group without hypertension (52.9% vs 26.7%, p<0.01). Hypertensive patients with concomitant overweight, central obesity, smoking increasing risks of insulin resistance (OR was 2.032, 3.288 and 2.012 sequently, p<0.05). Conclusion: Cardiovascular risk factors including overweight, central obesity, smoking were significantly associated with increasing risks of insulin resistance in patients with primary hypertension.