Nghiên cứu tác dụng điều trị dự phòng suy thận mạn của dịch chiết cây hạ khô thảo nam (Blumea lacera (Burn. f.) DC) trên động vật thực nghiệm

Abstract

Objective: To evaluate the preventive effectiveness of Blumea lacera extract on chronic renal failure by adenine in animal model. Subject and method: Blumea lacera was extracted by 96% ethanol three time, then the liquid was evaporated with low pressure to get EtOH extract. Swiss mice were devised in three groups: (1) Control group, distilled water ingestion. (2) Prevention group (M): Adenine oral administration (100mg/kg) every 2 days, in other day, Blumea lacera EtOH extract was oral administrated (equivalent to 8g rude/kg). (3) Renal failure group (ST): Adenine oral administration (100mg/kg) every 2 days. Animal was monitored within 35 days as whole body condition, weight, dead and other parameter such as blood cell count, urea, creatine, were identified. Result: At the end of 35 day duration, the similarity between control group and M group was identified. ST group significantly showed the higher in dead rate, urea and creatine concentration than other groups, red blood cell was significantly lower than those in other groups. Conclusion: Blumea lacera EtOH extract showed the renal failure prevention on renal failure animal model by adenine.