ISSN: 1859 - 2872
Plasma cell-free DNA of Epstein-Barr virus in management of nasopharyngeal carcinoma
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Keywords
Epstein-Barr virus, nasopharyngeal carcinoma
Abstract
Nasopharyngeal carcinoma (NPC) is one of the most common cancers in Asia country, including Vietnam. The strong association between NPC and Epstein-Barr virus (EBV) has been reported in many literature show that EBV genome has been determined in almost NPC tumors. Cell-free DNA of EBV in plasma (cf EBV DNA) was demonstrated as a useful biomarker for early detection and monitoring of NPC. This review will mention the role of cf EBV DNA in early detection, follow up and prognosis in post-treatment, the relation between cf EBV DNA concentrations and stages of disease, size of tumors.
Article Details
References
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2. Vokes EE, Liebowitz DN, and Weichselbaum RR (1997) Nasopharyngeal carcinoma. Lancet 350(9084): 1087-1091.
3. Mutirangura A et al (1998) Epstein-Barr viral DNA in serum of patients with nasopharyngeal carcinoma. Clin Cancer Res 4(3): 665-669.
4. Ho HT et al (2017) Establishment of ultrasensitive PCR assay targeting cell-free EBV DNA for early detection of nasopharyngeal carcinoma. Vietnam Journal of Science, Technology and Engineering 59(3): 7.
5. Chan KC et al (2013) Early detection of nasopharyngeal carcinoma by plasma Epstein-Barr virus DNA analysis in a surveillance program. Cancer 119(10): 1838-1844.
6. Chan KCA et al (2017) Analysis of plasma Epstein-Barr virus DNA to screen for nasopharyngeal cancer. N Engl J Med 377(6): 513-522.
7. Lo YM et al (1999) Quantitative analysis of cell-free Epstein-Barr virus DNA in plasma of patients with nasopharyngeal carcinoma. Cancer Res 59(6): 1188-1191.
8. YM L et al (1999) Quantitative and temporal correlation between circulating cell-free Epstein-Barr virus DNA and tumor recurrence in nasopharyngeal carcinoma. Cancer Res 59(21): 5452-5455.
9. Wang WY et al (2011) Plasma Epstein-Barr virus DNA screening followed by (1) (8)F-fluoro-2-deoxy-D-glucose positron emission tomography in detecting posttreatment failures of nasopharyngeal carcinoma. Cancer 117(19): 4452-4459.
10. Chan AT et al (2002) Plasma Epstein-Barr virus DNA and residual disease after radiotherapy for undifferentiated nasopharyngeal carcinoma. J Natl Cancer Inst 94(21): 1614-1619.
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How to Cite
Ho HuuT., Trieu ThiN., Do TramA., Nguyen Dinh UngU., Bui TienS., Hoang DaoC., & Nghiem DucT. (2020). Plasma cell-free DNA of Epstein-Barr virus in management of nasopharyngeal carcinoma. Tạp Chí Y Dược lâm sàng 108, 13(6), 127-131. Retrieved from https://tcydls108.benhvien108.vn/index.php/YDLS/article/view/392