Nghiên cứu nồng độ hormone estradiol, progesterone và testosterone huyết thanh ở bệnh nhân nữ mắc trứng cá thể thông thường

Abstract

Objective: Evaluation of the serum testosterone, estradiol, and progesterone levels and the correlation of hormonal alterations with the severity of acne in women with acne vulgaris. Subject and method: Analysed 175 women with acne vulgaris examined at the Dermal Clinic - the 103 Military Hospital. Assessment of serum estradiol, progesterone, and testosterone by chemiluminescence technique and compared with the healthy control group. Result: Increased serum hormone levels in women with acne vulgaris were accounted for 29.14%, and hyperandrogenism was accounted for 16.0% of cases. We found that the identified significant differences for testosterone levels (mean value, 55.67 ± 25.56ng/dL vs. 38.37 ± 10.16, p<0.05) were higher in group acne patients, compared with hormone levels in controls. And estradiol levels (323.15 ± 93.30 vs. 370 ± 58.88pmol/l, p<0.05) were lower in group patients with acne vulgaris. No statistically significant differences were found for progesterone (0.60 ± 0.38 vs 0.50 ± 0.15ng/ml, p>0.05) levels. Moreover, we did not find the relationship between serum hormone levels and the severity of acne vulgaris. Conclusion: Women acne vulgaris had serum testosterone levels significantly higher than the controls and have the estradiol levels significantly lower than the healthy women. Progesterone levels were no significant difference between two groups. However, hormonal alterations were no correlation with the severity of acne.