ISSN: 1859 - 2872
Analysis of analgesic-related drug problems in postoperative patients at Military Central Hospital 108
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Abstract
Objective: To analyze drug-related problems (DRPs) associated with analgesic use in postoperative patients in the Department of Trauma and Orthopedics. Subject and method: A prospective descriptive study was conducted involving 140 patients who underwent surgery between February 11 and March 18, 2025. Pain intensity was assessed using the Numerical Rating Scale (NRS), and DRPs were analyzed according to the Pharmaceutical Care Network Europe (PCNE) classification. Result: Males accounted for 64% of the cohort, and patients over 60 years old accounted for 43%. On the first post-operative day, 100% of the patients received analgesics. Oral paracetamol and celecoxib were the most frequently used peripheral analgesics. A combination regimen of 4 drugs was predominant on the first day (41%). The rate of severe pain decreased from 37% on day 1 to 0% on day 5 post-surgery. The average DRP rate was highest on day 1 (1.51 DRPs/patient) and gradually decreased to 0.02 on day 5. The most common causes of DRPs were underdosing (31%) and insufficient dosing frequency (31%), primarily associated with paracetamol. Conclusion: Analgesic management in the department was associated with a progressive reduction in pain intensity over time. However, optimization of drug dosages and dosing intervals is needed to minimize DRPs and improve postoperative pain management.
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References
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