Khảo sát một số đặc điểm lâm sàng, cận lâm sàng hội chứng Cushing ở bệnh nhân dùng glucocorticoids

Abstract

Objective: Describe the clinical manifestations and investigators including the level of cortisol in serum of iatrogenic Cushing syndrome patients at 8 hour and 20 hour. Subject and method: Prospective, descriptive, cross-sectional study. We examined the clinical signs and symptoms and investigated the laboratories of 110 iatrogenic Cushing's syndrome patients admitted in Rheumatology Department of the 108 Military Central Hospital from January 2015 to January 2017. Result: Common symptoms were: “moon” face (93.6%), red face (80.0%), frail (80.0%), thin skin (76.4%), subcutaneous hemorrhage (39.1%), depression (20.0%), hirsutism in female (66.7%), low libido (70.9%). Laboratories: Leukocytosis (47.3%), hyperglycemia (59.1%), high cholesterol (55.9%), hypertriglycemia (59.8%), low cortisol 8 hour (51.0%), low cortisol 20 hour (46.7%), reversed cortisol (55.4%). Conclusion: Clinical symptoms of iatrogenic Cushing syndrome are varied, the level of serum cortisol at 8 hour and 20 hour can be lower or reversed in the major part of the study group.