Recrudescence or reinfection of H. pylori of duodenal ulcer patients after eradication in E Hospital

  • Anh Do Nguyet E Hospital
  • Vinh Nguyen Thuy E Hospital
  • Hanh Nguyen Thi Hong Institute of Biotechnology
  • Thuy Nguyen Thi Dieu Institute of Biotechnology

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Keywords

H. pylori, recrudescence, reinfection, duodenal ulcer

Abstract

Objective: The aim of this study is to differantiate recrudescence from reinfection H. pylori after eradication therapy in duodenal ulcer. Subject and method: After successful eradication of H. pylori, 303 patients were followed up by endoscopy and rapid urease test. In recurrent patients, H. pylori strains isolated initially and after recurrence were compared using PCR-based restriction fragment length polymorphism (RFLP) analysis. Result: Recurrence of H. pylori occurred in 20 of 52 patients (38.5%) at follow-up time from 6 months to 31 months. PCR-based RFLP analysis of H. pylori strains isolated initially and after recurrence showed that 27.8% of bacteria were the same strains (Recrudescence) and 72.2% were different strains (reinfection). Conclusion: The rate of reinfection higher than recrudescence make the clinicians and community to have activities to control H. pylori transmission sources beside effective eradication therapy.

Article Details

References

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Published
Dec 15, 2019
Issue
Volume 14 - No 7/2019
Section
Articles
How to Cite
Do NguyetA., Nguyen ThuyV., Nguyen Thi HongH., & Nguyen Thi DieuT. (2019). Recrudescence or reinfection of H. pylori of duodenal ulcer patients after eradication in E Hospital. Tạp Chí Y Dược lâm sàng 108, 14(7). Retrieved from https://tcydls108.benhvien108.vn/index.php/YDLS/article/view/31