ISSN: 1859 - 2872
Characteristics of HSP110 protein concentration in tissue and its relationship with clinical and paraclinical characteristics in patients with colorectal cancer
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Abstract
Objective: To evaluate HSP110 protein concentration in colorectal cancer (CRC) tissues and determine its association with clinical and paraclinical characteristics in CRC patients. Subject and method: A cross-sectional descriptive study was conducted on 110 patients with colorectal cancer undergoing surgery (case group) and 52 patients with colorectal polyps (control group) confirmed by histopathology at 108 Military Central Hospital from May 2017 to December 2020. HSP110 protein concentrations in cancer and polyp tissues were quantified using the ELISA method (pg/mg). Clinical (age, gender, disease stage) and paraclinical data (tumor characteristics, histopathology) were collected using a standardized medical record form. Data were presented as median (Q1–Q3); Mann–Whitney U and Kruskal–Wallis tests were used to compare HSP110 concentrations between groups. A p-value < 0.05 was considered statistically significant. Result: The median HSP110 concentration in CRC tissues was 14.8 (12.1-19.0) pg/mg, which was lower than that in the colorectal polyp group [15.8 (10.4-24.5) pg/mg], but the difference was not statistically significant (p=0.462). Within the CRC group, the median HSP110 concentration in males [15.8 (12.8-19.1) pg/mg] was significantly higher than in females [12.7 (10.6-17.0) pg/mg] (p=0.006). No significant differences in HSP110 concentrations were found regarding age groups, disease stages, or other paraclinical features (tumor location, shape, size, histopathological type, differentiation grade, vascular invasion, perineural invasion, depth of invasion, and metastasis) (p > 0.05). Conclusion: HSP110 protein concentration in CRC tissues was lower than in colorectal polyp tissues, but without statistical significance (p=0.462). In the CRC group, HSP110 tissue concentration was associated with gender (higher in males; p=0.006), while no associations were observed with age, disease stage, or other paraclinical characteristics.
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References
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