ISSN: 1859 - 2872
Evaluating the impact of perioperative factors on early allograft dysfunction
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Abstract
Objective: To evaluate the impact of perioperative factors on early allograft dysfunction (EAD) in patients undergoing liver transplantation from living donors. Subjects and Methods: A descriptive, retrospective study was conducted on 198 patients who underwent living donor liver transplantation at the Central Military Hospital 108 from January 2020 to June 2025. Results: The EAD rate was 15.2%. Independent predictive factors for EAD included pre-transplant MELD score (OR = 1.06; p<0.001), warm ischemia time (WIT) (OR = 1.09; p=0.001), and lactate level on day 1 (OR = 1.39; p<0.001). A combined predictive model incorporating these three independent factors demonstrated good predictive value for EAD with an AUC = 0.812; sensitivity = 73.3% and specificity = 78.4%; p<0.001. Conclusion: Perioperative factors, including the pre-transplant MELD score, warm ischemia time, and lactate level on day 1, significantly impact the outcome of EAD after liver transplantation. The combined predictive model using these three factors provides good predictive value and has potential clinical applications.
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References
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