ISSN: 1859 - 2872
Association between perioperative blood transfusion and early postoperative cognitive dysfunction in elderly patients following hip and knee joint arthroplasty
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Abstract
Background: Accumulating evidence suggests that enhanced inflammatory responses contribute to the pathogenesis of postoperative cognitive dysfunction. Blood transfusion can trigger an enhancement of acute inflammatory responses. Therefore, we hypothesized that perioperative blood transfusion is associated with postoperative cognitive dysfunction in elderly patients following hip joint arthroplasty. Subject and method: Elderly patients (≥ 60 years) receiving spinal anesthesia for joint arthroplasty. Design of this study is longitudinal observational, prospective, single-center. Result: 22,5% of elderly patients had postoperative cognitive dysfunction for joint arthroplasty and received spinal anesthesia in the first 5 days of surgery. Multivariable Cox regression analysis noted that perioperative blood transfusion over 2 units (p=0.01) was a risk factor for postoperative cognitive dysfunction. Conclusion: Of all the 107 patients, 24 (22,5%) developed postoperative cognitive dysfunction in the first 5 days. Perioperative blood transfusion over 2 units is a risk factor for postoperative cognitive dysfunction in the elderly patients after spinal anesthesia for hip and knee joint arthroplasty.
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References
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