Effect of reducing triglyceride and cholesterol of plasma exchange therapy in patients with hypertriglyceridemia-induced acute pancreatitis

  • Hoa Do Thanh 108 Military Hospital
  • Hoa Le Thi Viet 108 Military Hospital
  • Binh Nguyen Gia Bach Mai Hospital
  • Duong Le Xuan 108 Military Hospital
  • Ghi Nguyen Hai 108 Military Hospital

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Keywords

Hypertriglyceridemia, acute pancreatitis, plasma exchange

Abstract

Objective: To evaluate the effectiveness of plasma exchange therapy (PEX) in patients with hypertriglyceridemia-induced acute pancreatitis. Subject and method: 165 patients with hypertriglyceridemia-induced acute pancreatitis treated at Bach Mai Hospital from 2016 to 2019 were included in the study. Patients were tested for cholesterol and triglycerides before and after PEX. Result: TG changed significantly after PEX, after the first PEX, TG decreased from 31.87mmol/l to 9.3mmol/l, cholesterol decreased from 18.74mmol/l to 7.12mmol/l. After the 3rd PEX, TG decreased from 31.87mmol/l to 7.31mmol/l (respectively 77%), cholesterol decreased from 18.74mmol/l to 3.22mmol/l (equivalent to 82.8%). Conclusion: In patients with hypertriglyceridemia-induced acute pancreatitis, the PEX group experienced a faster reduction in triglycerides and cholesterol compared to the non-PEX group.

Article Details

References

1. Chatila AT, Bilal M, Guturu P (2019) Evaluation and management of acute pancreatitis. World J Clin Cases 7(9): 1006-1020.
2. Baranyai T et al (2010) Acute pancreatitis caused by hypertriglyceridemia. Orv Hetil 151(45): 1869-1874.
3. Garg R, Rustagi T (2018) Management of hypertriglyceridemia induced acute pancreatitis. Biomed Res Int. 2018: 4721357.
4. Gupta A, Wosik J, Philips S (2016) Hypertriglyceridemia-Induced pancreatitis. J Gen Intern Med 31(2): 252.
5. Maradana S et al (2019) Hypertriglyceridemia induced pancreatitis due to brentuximab therapy: First case report. Cureus11(7): 5138.
6. Banks PA, Freeman ML (2016) Practice guidelines in acute pancreatitis. Am J Gastroenterol 101(10): 2379-2400.
7. Stefanutti C et al (2009) Therapeutic plasma exchange in patients with severe hypertriglyceridemia: A multicenter study. Artif Organs 33(12): 1096-1102.
8. Lennertz A et al (1999) Therapeutic plasma exchange in patients with chylomicronemia syndrome complicated by acute pancreatitis. Ther Apher 3(3): 227-233.
9. Yeh JH, Chen JH, Chiu HC (2003) Plasmapheresis for hyperlipidemic pancreatitis. J Clin Apher 18(4): 181-185.
10. Gubensek J et al (2009) Treatment of hyperlipidemic acute pancreatitis with plasma exchange: A single-center experience. Ther Apher Dial 13(4): 314-317.

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Published
Dec 15, 2019
Issue
Volume 14 - No 7/2019
Section
Articles
How to Cite
Do ThanhH., Le Thi VietH., Nguyen GiaB., Le XuanD., & Nguyen HaiG. (2019). Effect of reducing triglyceride and cholesterol of plasma exchange therapy in patients with hypertriglyceridemia-induced acute pancreatitis. Tạp Chí Y Dược lâm sàng 108, 14(7). Retrieved from https://tcydls108.benhvien108.vn/index.php/YDLS/article/view/29