Nghiên cứu tần suất, đặc điểm lâm sàng, cận lâm sàng viêm phổi do Chlamydia pneumoniae ở trẻ em

Abstract

Objective: To describe frequency, clinical features and features of C. pneumoniae in the community - acquired pneumonia. Subject and method: Nasopharyngeal swabs or aspirates and enzyme-linked immunosorbent assay in double the serum samples of total 722 patients (ranging 1 to 15 years of age) with the clinical diagnosis of acute lower respiratory tract infections, admitted to Respiratory Department of National Children Hospital in Vietnam during July 2010 - Mach 2012, were collected. Multiplex PCR and IgM antibody against C. pneumoniae were used to detect C. pneumoniae in those specimens. Result: Percentage of community - acquired pneumonia due to C. pneumoniae, was 3.74%. co-infection of C. pneumoniae with M. pneumoniae in 14 cases (51.9%). Mean age was 3.9 ± 3.7 years (range 1 - 15).  Bệnh gặp ở cả 2 giới, mọi lứa tuổi , hay gặp thuổi học đường.The disease affects more female than male groups (p<0.05).bệnh xảy ra quanh năm, xu hướng tăng vào mùa hè. The Disease occurs throughout the year and gets its peak during summer time. Physical examination no findings symptom or sight was 51.9% other than fever, cough, crepitations, crackles. We found that CRP, WBC and neutrophil were elevated among C. pneumoniae groups. Chest X-ray result of atypical pneumonia due to C. pneumoniae showed that most of patchy infiltration and consolidation. Conclusion: C. pneumoniae was pathogens of community - acquired pneumonia in hospitalized children in Vietnam. The diagnosis is easy to miss because of atypical clinical symptoms and signs. This confirms the important role of the fortes and advantages of PCR assay that diagnosis pathogens quickly and accurately for atypical pneumonia.