Khảo sát thực trạng đau và biến cố bất lợi của thuốc giảm đau ở bệnh nhân ung thư tại Bệnh viện Trung ương Quân đội 108

Abstract

Objective: To assess the status of pain and adverse drug events (ADEs) related to analgesics in cancer patients at the 108 Military Central Hospital. Subject and method: A prospective, cross-sectional study with evaluations at admission and after 7 days. Data were collected through direct patient interviews using the Brief Pain Inventory (BPI) and ADE detection tools, combined with medical record review. Subjects: 454 cancer patients treated at the Oncology Center, 108 Military Central Hospital, from July to November 2025. Result: At baseline, 15.8% experienced severe pain, which decreased to 1.4% after 7 days (p = 0.0006). A total of 609 ADEs were recorded (1.3 per patient), with dizziness (58.4%), drowsiness, and constipation being most common. Tramadol + paracetamol was the most frequently used analgesic and also caused the most ADEs. Conclusion: Pain control was effective within 7 days, but ADEs especially with opioid combinations were frequent. Enhanced monitoring and involvement of clinical pharmacists are essential for safer pain management.