Graft-versus-host disease following liver transplantation: A case report and therapeutic challenges

  • Ngô Đình Trung Bệnh viện Trung ương Quân đội 108
  • Ngô Thị Minh Hạnh Bệnh viện Trung ương Quân đội 108
  • Lê Nam Khánh Bệnh viện Trung ương Quân đội 108

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Keywords

Acute graft-versus-host disease, liver transplantation, post-transplant complication

Abstract

Graft-versus-Host Disease (GVHD) is a rare but highly fatal complication in liver transplant recipients due to poor response to current treatment strategies. We report a case of a 45-year-old male patient who underwent liver transplantation from a brain-dead donor with an identical ABO blood group at the 108 Military Central Hospital. In the fourth week post-transplant, the patient developed prolonged high fever, generalized skin rash, and diarrhea. Skin biopsy confirmed the diagnosis of GVHD. Despite treatment with interleukin-2 inhibitors and high-dose corticosteroids, the patient showed no clinical improvement. The condition rapidly progressed to septic shock, multi-organ failure, and death. This case highlights the challenges in early diagnosis and effective management of GVHD following liver transplantation.

Article Details

References

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Published
Jun 12, 2025
DOI: https://doi.org/10.52389/ydls.v20i4.2704
Issue
Volume 20-No 4/2025
Section
Articles
How to Cite
TrungN. Đình, HạnhN. T. M., & KhánhL. N. (2025). Graft-versus-host disease following liver transplantation: A case report and therapeutic challenges. Tạp Chí Y Dược lâm sàng 108, 20(4). https://doi.org/10.52389/ydls.v20i4.2704