Serological DKK1 acquires no diagnostic value in identification of hepatitis B virus related hepatocellular carcinoma

  • Trung Ngo Tat 108 Military Central Hospital
  • Trung Pham Quang 108 Military Central Hospital
  • Tuan Nguyen Thi 108 Military Central Hospital
  • Duong Dang Chieu 108 Military Central Hospital
  • Hoan Phan Quoc 108 Military Central Hospital
  • Song Le Huu 108 Military Central Hospital

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Keywords

Hepatocellular carcinoma, hepatitis B virus, DKK1

Abstract

Objective: To investigate the clinical significance of serological DKK1 level in the diagnosis of hepatitis B virus (HBV) related hepatocellular carcinoma (HCC). Subject and method: Plasma DKK1 concentrations from 43 HBV carriers, 35 liver cirrhosis related HBV and 112 HCC related HBV were measured by ELISA, whereas receiver operating characteristics (ROC) was used to calculate diagnostic accuracy. Result: The DKK1 levels were not different between HCC and other groups (p>0.05). The value diagnosis of DKK1 was quite low (HCC vs liver cirrhosis, AUC = 0.553, HCC vs chronic hepatitis B, AUC = 0.374). AFP was not supported by DKK1 in the diagnostic performance of HCC (HCC vs liver cirrhosis, AUC (DKK1 + AFP) = 0.691 compared with AUC (AFP) = 0.664, HCC vs chronic hepatitis B, AUC (DKK1 + AFP) = 0.295 compared with AUC - (AFP) = 0.704). Conclusion: Serum DKK1 cannot be used for detection of liver cancer in Vietnam.


 

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References

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Published
Nov 29, 2020
Issue
Volume 14 - No 2/2019
Section
Articles
How to Cite
Ngo TatT., Pham QuangT., Nguyen ThiT., Dang ChieuD., Phan QuocH., & Le HuuS. (2020). Serological DKK1 acquires no diagnostic value in identification of hepatitis B virus related hepatocellular carcinoma. Tạp Chí Y Dược lâm sàng 108, 14(2), 67-71. Retrieved from https://tcydls108.benhvien108.vn/index.php/YDLS/article/view/265