ISSN: 1859 - 2872
Remark on procurement, perfusion and preservation of brain death lung donor at 108 Military Central Hospital
Main Article Content
Keywords
Lung transplantation, brain-dead donor.
Abstract
Objective: Summary of some technical characteristics in procurement, perfusion and preservation of brain death lung donor. Subject and method: Observating 04 brain death lung donations, the donor age was 31 - 49 years old, 01 brain trauma patient and 03 non-traumatic brain damage patients. Result and conclusion: After harvesting, the lung need to be completely paralyzed and preserved in a cold solution at 4 degrees Celsius to reduce metabolism and prevent oxydant creating. The cold ischemic time was 2.5 - 7.75 hours for the first lung, 3.5 - 10.92 hours for the second lung. The preservation solution were extracellular solutions such as Perfadex and Custodiol.
Article Details
References
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12. Mordant P, Bonnette P, Puyo P, Sage E, Grenet D, Stern M et al (2010) Advances in lung transplantation for cystic fibrosis that may improve outcome. European journal of cardio-thoracic surgery 38: 637-643.
13. Steen S, Ingemansson R, Eriksson L, Pierre L, Algotsson L, Wierup P et al (2007) First human transplantation of a nonacceptable donor lung after reconditioning ex vivo. Ann Thorac Surg 83(6): 2191-2194.
14. Ahmad K, Pluhacek JL, Brown AWJPT (2020) Ex vivo lung perfusion: A review of current and future application in lung transplantation. Pulm Ther 8(2): 149-165.
2. Sharma G, Goodwin J (2006) Effect on aging on respiratory system physiology and immunology. Clin Interv Aging 1: 253-260.
3. Ciccone AM, Stewart KC, Meyers BF, Guthrie TJ, Battafarano RJ, Trulock EP, Cooper JD, Patterson GA (2002) Does donor cause of death affect the outcome of lung transplantation? J Thorac Cardiovasc Surg 123(3):429-34; discussion 434-6. doi: 10.1067/mtc.2002.120732.
4. Costa J, D'Ovidio F, Sonett JR (2016) Donor selection and management. Lung Transplantation: Principles and Practice: CRC Press: 75-86.
5. Nguyễn Hữu Ước, Phạm Tiến Quân, Vũ Văn Thời và cộng sự (2021) Kết quả ca ghép hai phổi đầu tiên từ người cho đa tạng chết não tại Bệnh viện Hữu nghị Việt Đức. Tạp chí Y học Việt Nam 498(1).
6. Munshi L, Keshavjee S, Cypel MJTLRM (2013) Donor management and lung preservation for lung transplantation. Lancet Respir Med 1(4): 318-328.
7. Lund LH, Khush KK, Cherikh WS, Goldfarb S, Kucheryavaya AY, Levvey BJ et al (2017) The Registry of the International Society for Heart and Lung Transplantation: Thirty-fourth adult heart transplantation report 2017; focus theme: Allograft ischemic time. J Heart Lung Transplant 36(10): 1037-1046.
8. Lannon J, Ball A, Ramesh B, Yonan N, Clark S, Mascaro J et al (2014) The effect of cold and warm ischemia time on survival after lung transplantation in a large national cohort. The Journal of Heart and Lung Transplantation 33(S4): 94.
9. Sommer W, Warnecke G (2016) Donor lung preservation. LUNG Transplantation: Principles and Practice: CRC Press: 97-104.
10. Oto T, Griffiths AP, Rosenfeldt F, Levvey BJ, Williams TJ, Snell GIJTAots (2006) Early outcomes comparing Perfadex, Euro-Collins, and Papworth solutions in lung transplantation. The Annals of Thoracic Surgery 82(5): 1842-1848.
11. Copeland H, Hayanga JA, Neyrinck A, MacDonald P, Dellgren G, Bertolotti A et al (2020) Donor heart and lung procurement: A consensus statement. J Heart Lung Transplant 39(6): 501-517.
12. Mordant P, Bonnette P, Puyo P, Sage E, Grenet D, Stern M et al (2010) Advances in lung transplantation for cystic fibrosis that may improve outcome. European journal of cardio-thoracic surgery 38: 637-643.
13. Steen S, Ingemansson R, Eriksson L, Pierre L, Algotsson L, Wierup P et al (2007) First human transplantation of a nonacceptable donor lung after reconditioning ex vivo. Ann Thorac Surg 83(6): 2191-2194.
14. Ahmad K, Pluhacek JL, Brown AWJPT (2020) Ex vivo lung perfusion: A review of current and future application in lung transplantation. Pulm Ther 8(2): 149-165.
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Published
Jan 20, 2025
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How to Cite
HảiN. V., KiểmT. T., Dũng Đặng T., ThắngN. Đức, HoàngN. V., BìnhN. T., HưngN. Q., HảiN. H., GiangM. A., HàN. V. X., & SơnL. H. (2025). Remark on procurement, perfusion and preservation of brain death lung donor at 108 Military Central Hospital. Tạp Chí Y Dược lâm sàng 108, 20(1). https://doi.org/10.52389/ydls.v20i1.2571