Biến đổi sức cản và điện kháng đường thở đo bằng kỹ thuật dao động cưỡng bức trên bệnh nhân bệnh phổi tắc nghẽn mạn tính

Abstract

Objective: To assess the changes of respiratory resistance and reactance using forced oscillation technique in chronic obstructive pulmonary disease (COPD) patients. Subject and method: The study has been done in 108 Military Central Hospital from October 2017 to November 2018, among 200 normal subjects and 200 COPD patients, included 150 stable COPD patients and 50 COPD patients with exacerbations. Respiratory resistance (Rrs5 and Rrs20) and reactance (Xrs5) and pulmonary function tests were measured by MostGraph-02 (Chest M.I., Co. Ltd., Tokyo, Japan) in 200 normal subjects and 150 stable COPD patients. For 50 COPD patients with exacerbations, only respiratory resistance (Rrs5 and Rrs20) and reactance (Xrs5) were measured. Result: Parameters of pulmonary function tests in patients had been decreased: FVC: 2.81 ± 0.52L; FVC%: 86.6 ± 12.8%, FEV1: 0.85 ± 0.34L, FEV1%: 53.1 ± 22.9%, FEV1/FVC%: 52.4 ± 10.6%, FEF 25-75%: 25.6 ± 13.8%, PEF%: 27.4 ± 14.9%. Respiratory resistance and reactance in stable COPD patients: Rrs5: 0.403 ± 0.083kPa/L/s, Rrs20: 0.338 ± 0.064kPa/L/s, Xrs5: -0.132 ± 0.087kPa/L/s, in exacerbations COPD patients Rrs5: 0.501 ± 0.135kPa/L/s, Rrs20: 0.383 ± 0.098kPa/L/s, Xrs5: -0.176 ± 0.063kPa/L/s. Respiratory resistance Rrs5 and Rrs20 were higher and reactance Rrs5 more negative in exacerbations COPD patients than in stable COPD patients. Respiratory resistance Rrs5 and Rrs20 were higher and reactance Xrs5 more negative in patients than in normal subjects (Rrs5: 0.332 ± 0.065kPa/L/s, Rrs20: 0.251 ± 0.078kPa/L/s, Xrs5: -0.0061 ± 0.0012kPa/L/s). Conclusion: Respiratory resistance Rrs5 and Rrs20 were higher and reactance Xrs5 more negative in patients than in normal subjects with p<0.05.