Nghiên cứu đặc điểm về rối loạn trí nhớ trên bệnh nhân động kinh là người trưởng thành điều trị bằng phenobarbital

Abstract

Objective: To describe and analyze some characteristics of memory disorders in adult epileptic grand mal seizures treated with phenobarbital. Subject and method: Cross-sectional descriptive studies were compared with 100 adult epileptic grand mal seizures. Patients were divided into two groups: Group 1 was the patient who used phenobarbital at the local health service under the National Program; group 2 was the patients who received other antiepileptic drugs taken at the Bach Mai Hospital. Each patient was examined for clinical and make the tests of memory. Then compare the results obtained from the two groups. Result: Memory impairment in patients taking phenobarbital was 64% and higher 2.46 times than that of the other anti-epileptic drugs (36%) (OR = 2.46, Cl 95%: 1.1 - 5.5, p=0.028). Memory disorders were mainly seen in the age of the onset seizures below the age of 6 years was 95% in the phenobarbital group and 80% in the other group. However, there was no significant difference between the two groups for p>0.05. The duration of phenobarbital over 5 years was 74.4% of patients with memory disorders and higher 3.31 times more than other anti-epileptic drugs (53.3%). The difference was statistically significant (OR = 3.31, CI 95%: 1.31 - 8.37, p=0.013). Conclusion: Patients taking phenobarbital ware memory disorders higher 2.6 times than in other anti-epileptic drugs. Duration of using anti-epileptic over 5 years in the group of phenobarbital is 3.31 times higher rate of memory disorders than other drugs.