Phân tích hiệu quả can thiệp dược lâm sàng về các vấn đề liên quan đến thời điểm dùng-cách dùng thuốc ở bệnh nhân cao tuổi điều trị ngoại trú tại Bệnh viện Đa khoa Đống Đa

Abstract

Objective: To determine common drug-related problems (DRP) and analyse clinical pharmacists' interventions on DRP in timing and administration methods in prescriptions of elderly outpatients in Dong Da General Hospital. Subject and method: The study consists of 3 phases: (1) Pre-intervention: cross-sectional descriptive study to determine DRP in outpatient prescriptions and through patient interviews (01/10/2023-31/10/2023), (2) Interventions to provide real-time information on the electronic prescription system (01/11/2023-30/11/2023), and (3) Evaluation phase (10/12/2023–31/12/2023) to assess the impact of the interventions by comparing the number of DRP in prescriptions, the percentage of patients taking medications at appropriate times, and the percentage of patients who would not chew, break, or crush specially formulated medications before and after the interventions. Result: 687 DRP were identified in 515 outpatient prescriptions for elderly patients, in which 60.8% of prescriptions had at least 1 DRP. The most common DRP were inappropriate timing of drug administration (14.7%), and lack of caution for not chewing, breaking, or crushing drugs with special formulations (73.9%). After the intervention, the rate of prescriptions with DRP related to timing and administration methods of drugs decreased significantly from 57.5% to 34.6% (p<0.001). The rate of patients with appropriate timing of drug use and the rate of patients who would not chew, break, or crush specially formulated medications both increased significantly. Conclusion: Pharmacists’ interventions significantly reduced DRP regarding timing and administration methods in outpatient prescriptions.