Evaluation of left ventricular diastolic function using conventional and speckle tracking echocardiography in cirrhosis patients before and after liver transplantation
Main Article Content
Keywords
Abstract
Objective: To evaluate left ventricular diastolic function in cirrhotic patients before and after liver transplant. Subject and method: This was prospective, observational study on 51 cirrhosis patients undergoing liver transplant at 108 Military Central Hospital between February 2022 and September 2023. Result: Left ventricular diastolic function in cirrhotic patients significantly improved after liver transplantation. The proportion of patients with left ventricular diastolic dysfunction decreased from 25.5% to 13.7% (p<0.05). The left atrial volume index (LAVI) after transplantation was significantly lower than before transplantation (30ml/m² vs. 28ml/m², p<0.05). LAVI and left ventricular mass index (LVMI) were identified as independent predictors of mortality, with LAVI (OR = 1.127; CI 95%: 1.043-1.217, p<0.05) and LVMI (OR = 1.010; CI 95%: 1.001-1.022, p<0.05). Conclusion: The left ventricular diastolic function of patients with cirrhosis improved after liver transplantation. LAVI and LVMI were independent predictors of mortality in patients with cirrhosis undergoing liver transplantation.
Article Details
References
2. Pozzi M, Carugo S, Boari G et al (1997) Evidence of functional and structural cardiac abnormalities in cirrhotic patients with and without ascites. Hepatology (Baltimore, Md) 26(5): 1131-1137. doi:10.1002/hep.510260507.
3. Wong F, Liu P, Lilly L, Bomzon A, Blendis L (1999) Role of cardiac structural and functional abnormalities in the pathogenesis of hyperdynamic circulation and renal sodium retention in cirrhosis. Clinical science (London, England: 1979) 97(3): 259-267.
4. Kakar P, Gubitosa J, Gerula C (2021) Echocardiography in the liver transplant patient. Curr Cardiol Rep 23(8): 110. doi:10.1007/s11886-021-01531-1.
5. Ruíz-del-Árbol L, Achécar L, Serradilla R et al (2013) Diastolic dysfunction is a predictor of poor outcomes in patients with cirrhosis, portal hypertension, and a normal creatinine. Hepatology (Baltimore, Md) 58(5): 1732-1741. doi:10.1002/hep.26509.
6. Kasner M, Gaub R, Sinning D et al (2010) Global strain rate imaging for the estimation of diastolic function in HFNEF compared with pressure-volume loop analysis. European Journal of Echocardiography 11(9): 743-751. doi:10.1093/ejechocard/jeq060.
7. Martin P, DiMartini A, Feng S, Brown R, Fallon M (2014) Evaluation for liver transplantation in adults: 2013 practice guideline by the American Association for the Study of Liver Diseases and the American Society of Transplantation. Hepatology (Baltimore, Md) 59(3): 1144-1165. doi:10.1002/hep.26972.
8. Singal AG, Llovet JM, Yarchoan M et al (2023) AASLD Practice Guidance on prevention, diagnosis, and treatment of hepatocellular carcinoma. Hepatology (Baltimore, Md) 78(6): 1922-1965. doi:10.1097/hep.0000000000000466.
9. Lang RM, Badano LP, Mor-Avi V et al (2015) Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. Journal of the American Society of Echocardiography: Official publication of the American Society of Echocardiography 28(1): 1-39. doi:10.1016/j.echo.2014.10.003.
10. Torregrosa M, Aguadé S, Dos L, et al (2005) Cardiac alterations in cirrhosis: reversibility after liver transplantation. Journal of hepatology 42(1): 68-74. doi:10.1016/j.jhep.2004.09.008.
11. Dương Quang Huy (2016) Nghiên cứu lâm sàng, cận lâm sàng, hình thái và chức năng tim ở bệnh nhân xơ gan. Luận văn Tiến sỹ, Học viện Quân y.
12. Dowsley TF, Bayne DB, Langnas AN et al (2012) Diastolic dysfunction in patients with end-stage liver disease is associated with development of heart failure early after liver transplantation. Transplantation 94(6): 646-651. doi: 10.1097/TP.0b013e31825f0f97.