Nghiên cứu hình ảnh cộng hưởng từ sức căng khuếch tán và tưới máu thận ghép trên máy cộng hưởng từ 3.0Tesla

Abstract

Objective: To study Diffusion Tensor Imaging (DTI) and renal perfusion MRI in transplanted kidneys. Subject and method: The study included 45 patients with 45 transplanted kidneys, who underwent kidney transplantation at 108 Military Central Hospital between 2019 and 2023. Among them, 32 were male and 13 were female, with an average age of 39.41 ± 12.31 years for males and 40.92 ± 11.43 years for females. All patients underwent MRI using a 3.0T system (GE) in a cross-sectional descriptive study. Result: The average volume of the transplanted kidney was 160.9 ± 42.9ml. The average number of fiber bundles was 16,147.91 ± 5,022.04. The mean FA value for the entire kidney was 0.32 ± 0.04, and ADC was 2.26 ± 0.26. The FA values for the cortex of the transplanted kidney at the upper pole, mid-region, and lower pole were 0.24, 0.22, and 0.21, respectively. The corresponding ADC values were 2.62, 2.72, and 2.61. For the medulla, the FA values at the upper pole, mid-region, and lower pole were 0.46, 0.45, and 0.45, respectively. The corresponding ADC values were 2.60, 2.50, and 2.40. The average RBF in the renal cortex was higher than in the renal medulla across all regions. A positive correlation was found between medullary FA and estimated glomerular filtration rate (eGFR) (correlation coefficient r = 0.54, p<0.001), as well as between eGFR and medullary RBF (r = 0.3, p<0.05). Conclusion: Diffusion Tensor Imaging and non-contrast renal perfusion MRI represent valuable non-invasive diagnostic modalities for the early detection of post-transplant kidney injury. The FA and ADC parameters are instrumental in detecting and evaluating the structural integrity of the renal parenchyma and the diffusion of water within the transplanted kidney tissue. The RBF values enable the assessment of renal perfusion without the need for contrast agents, which can potentially compromise graft function.