ISSN: 1859 - 2872
Characteristics of white matter bundles of Alzheimer's patients on diffusion tensor imaging
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Abstract
Objective: Investigating pathological alterations in white matter bundles in Alzheimer's patients using 3.0 Tesla diffusion tensor imaging (DTI). Subject and method: A cross-sectional descriptive study was conducted on 30 Alzheimer's patients and a control group of 30 normal individuals from November 2019 to May 2022. The investigation focused on specific white matter bundles, including the corpus callosum, fornix-hippocampus, cingulum bundle, frontal-occipital fasciculus, corticospinal tract, thalamo-cingulum bundle, and cerebellar peduncle. Result: 3D reconstructions revealed no discernible differences in the tractography of white matter fibers between Alzheimer's patients and the control group. However, many significant statistical differences were observed in the reduction of fiber count, fiber length, voxel index, FA, and ADC increase of white matter bundles. Conclusion: In Alzheimer's disease, DTI indices alterations were identified in majority of investigated white matter bundles. DTI proves to be a effective method for investigating white matter changes in Alzheimer's patients.
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References
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