ISSN: 1859 - 2872
Understanding the relationship between HSP110DE9 mutation and endoscopic and histopathological characteristics of colorectal cancer patients
Main Article Content
Keywords
Abstract
Objective: To understand the relationship between HSP110DE9 mutation and endoscopic and histopathological characteristics of colorectal cancer. Subject and method: A cross-sectional descriptive study on 110 colorectal cancer patients examined and treated at 108 Military Central Hospital from 2017 to 2020. HSP110DE9 gene mutation was identified in colorectal cancer tissue by PCR (Polymerase Chain Reaction) and electrophoresis gel Agarose. Result: The rate of HSP110DE9 gene mutation in patients with colorectal cancer accounted for 38.2%. Regarding endoscopic characteristics, the results showed that there was no correlation between HSP110DE9 gene mutation and tumor location and size on endoscopy (p>0.05, Chi square test), but there was a correlation between tumor shape and HSP110DE9 mutation. In which, in the infiltrative ulcerative and infiltrative forms, the rate of HSP110DE9 mutation was higher than the non-mutated group (p<0.05, Chi square test). Regarding histopathological characteristics, there was no correlation between HSP110DE9 gene mutation and histopathological type, differentiation level, wall invasion level and lymph node metastasis of colorectal cancer (p>0.05, Chi square test). There was a correlation between distant metastasis and colorectal cancer stage and HSP110DE9 gene mutation. In which, distant metastatic colorectal cancer had a higher rate of HSP110DE9 gene mutation than those without mutation (21.4% vs. 5.9%) and in stage IV colorectal cancer patients, the rate of HSP110DE9 gene mutation was higher than those without HSP110DE9 gene mutation (21.4% vs. 5.9%), the difference was statistically significant (p<0.05, Chi square test). Conclusion: The study found a correlation between HSP110DE9 gene mutation and tumor shape on endoscopy, distant metastasis and colorectal cancer stage (p<0.05, Chi square test).
Article Details
References
2. Pockley AG (2002) Heat shock protein, Inflammation and cardiovascular díease. Circulation 105 : 1012-1017.
3. Eseigneuric R, Emjahed H, Egobbo J, Ejoly AL, Berthenet K, Eshirley S, Egarrido C (2011) Heat shock proteins as danger signals for cancer detection. Front Oncol 1: 37.
4. Dorard C, de Thonel A, Collura A et al (2011) Expression status of wild-type HSP110 correlates with HSP110 T17 deletion size and patient prognosis in microsatellite-unstable colorectal cance. Nature medicine 10(2011): 1283-1290.
5. Hrudka J, Jelínková K, Fišerová H et al (2021) Heat shock proteins 27, 70, and 110: Expression and prognostic significance in colorectal cancer. Cancers (Basel) (17):4407. doi: 10.3390/cancers13174407.
6. WHO (2019) WHO classification of tumours, 5th edition, Digestive system tumours WHO Classification of Tumours Group: 157-192.
7. American Joint Committee on Cancer (2017) AJCC Cancer Staging Manual, Eighth Edition. Springer: 251-274.
8. Falih Soliman N, Jasim Mohamad B (2022) Clinical and Histopathological Characteristics of Colorectal Cancer in Iraq between 2015-2021. Falih Soliman et al / Archives of Razi Institute 77(6): 2407-2413.
9. Ngô Thị Hoài (2022) Nghiên cứu hình ảnh nội soi, mô bệnh học và đột biến gen KRAS, BRAF trên bệnh nhân polyp tuyến và ung thư đại trực tràng. Luận án Tiến sĩ Y học, Viện Nghiên cứu khoa học Y dược lâm sàng 108.
10. Kim JH, Kim KJ, Rhee YY et al (2014) Expression status of wild-type HSP110 correlates with HSP110 T17 deletion size and patient prognosis in microsatellite-unstable colorectal cance. Modern Pathology 27: 443-453.
11. Collura A, Lagrange A, Svrcek M et al (2014) Patients with colorectal tumors with microsatellite instability and large deletions in HSP110 T17 have improved response to 5-fluorouracil–based chemotherapy. Gastroenterology: 401-411.
Article Sidebar
