ISSN: 1859 - 2872
Antibiotic resistance of Helicobacter pylori at the 108 Military Central Hospital in the period of 2019-2022
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Abstract
Objective: This study aimed to update the Helicobacter pylori (H. pylori) antibiotic resistance status over recent years. Subject and method: A total of 350 H. pylori strains were isolated from gastritis, peptic ulcer, and gastric cancer patients at 108 Military Central Hospital from 2019 to 2022. Antibiotic susceptibility tests were performed using the Epsilometer (E-test) technique. Result: The resistance rates to AC, CH, MZ, LE, and TC were 30.6%, 44.6%, 44%, 33.4%, and 9.14%, respectively. The rates of double-, triple-, quadruple-, and quintuple-antibiotic resistance among isolates were 33.1%, 15.1%, 4.3%, and 0.9%, respectively. The highest dual resistance rate was CH+MZ (19.7%), while the lowest was MZ+TC (4.9%). The strains showed a high level of resistance (MIC ≥ 256μg/mL) to CLR, 69.87% (109/156), MNZ, 73.37% (113/154), and (MIC ≥ 32µg/mL) to LE, 85.47% (100/117). MIC for AC and TC were low in most isolated strains. Conclusion: Most strains showed extremely high-level resistance of MZ, LE, and CH, while low-level resistance of TC and AC suggested that quadruple therapy including tetracycline/amoxicillin should be considered as an alternative strategy.
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References
2. Vu TB, Tran TNQ, Tran TQA, Vu DL, Hoang VT (2022) Antibiotic resistance of helicobacter pylori in patients with peptic ulcer. Medicina (Kaunas) 59(1)doi: 10.3390/medicina59010006.
3. Bujanda L, Nyssen OP, Vaira D et al (2021) Antibiotic resistance prevalence and trends in patients infected with Helicobacter pylori in the period 2013-2020: Results of the European Registry on H. pylori Management (Hp-EuReg). Antibiotics 10(9): 1058.
4. UK Standards for Microbiology Investigations. Identification of Helicobacter species Identification of Helicobacter species. 2022;
5. European Society of Clinical Microbiology and infectious Diseases. Clinical breakpoints - breakpoints and guidance. 2022;
6. Nguyễn Thị Chi, Hoàng Thúy Nga, Trần Thị Minh Châu, Trần Ngọc Ánh (2021) Kháng kháng sinh của Helicobacter pylori tại Bệnh viện Đại học Y Hà Nội từ 2018- 2020. Tạp chí khoa học tiêu hóa Việt Nam. Tập X- Số 65: tr. 4048-4056.
7. Hong TC, El-Omar EM, Kuo YT et al (2024) Primary antibiotic resistance of Helicobacter pylori in the Asia-Pacific region between 1990 and 2022: An updated systematic review and meta-analysis. Lancet Gastroenterol Hepatol 9(1): 56-67. doi:10.1016/s2468-1253(23)00281-9.
8. Binh TT, Shiota S, Nguyen LT, Yamaoka Y (2013) The incidence of primary antibiotic resistance of Helicobacter pylori in Vietnam. J Clin Gastroenterol 47(3): 233-228. doi:10.1097/MCG.0b013e3182676e2b.
9. Dang NQH, Ha TMT, Nguyen S-T et al (2020) High rates of clarithromycin and levofloxacin resistance of Helicobacter pylori in patients with chronic gastritis in the south east area of Vietnam. Journal of Global Antimicrobial Resistance 22: 620-624. doi:10.1016/j.jgar.2020.06.007.
10. Shao Y, Lin Y, Fang Z, Yan J, Zheng T, Ye G (2024) Analysis of Helicobacter pylori resistance in patients with different gastric diseases. Sci Rep 14(1):4912. doi:10.1038/s41598-024-55589-2.
11. White B, Winte M, DeSipio J, Phadtare S (2022) Clinical factors implicated in antibiotic resistance in helicobacter pylori patients. Microorganisms 10(2): 322.
12. Darraj MA (2024) Eradication Rate and Factors Influencing Helicobacter pylori Infection Clearance Using Standard Triple Therapy at a Single Centre in Jazan Region, Saudi Arabia: A Retrospective Study. Int J Gen Med 17: 2627-2634. doi: 10.2147/ijgm.S456865.
13. Dascălu RI, Bolocan A, Păduaru DN et al (2023) Multidrug resistance in Helicobacter pylori infection. Front Microbiol 14: 1128497. doi:10.3389/fmicb.2023.1128497.
14. Borka Balas R, Meliț LE, Mărginean CO (2023) Current worldwide trends in pediatric helicobacter pylori antimicrobial resistance. Children 10(2): 403.
15. Boyanova L, Hadzhiyski P, Gergova R, Markovska R (2023) Evolution of Helicobacter pylori Resistance to Antibiotics: A topic of increasing concern. Antibiotics 12(2):332.