Phân tích thực trạng sử dụng hoá trị liệu trên bệnh nhân ung thư vú tại Bệnh viện K

Abstract

Objective: To analyze chemotherapy indication, dosage, and administration among breast cancer patients. Subject and method: A cross-sectional study was conducted on medical records among breast cancer patients admitted to Internal Medicine Departments Five and Six at Vietnam National Cancer Hospital from 01/01/2024 to 31/03/2024 for chemotherapy. Result: The study included 220 patients with an average age of 51.0 ± 10.6, mainly in stages II and III (73.2%), and with HR+ /HER2- (67.7%). 62.8% of patients were prescribed adjuvant chemotherapy. The most popular regimens were the combination of taxan and anthracycline (61.8%) or taxan without anthracycline (34.1%). The proportions of chemicals used at doses greater than or equal to 90% of the recommended standard doses in the neoadjuvant/adjuvant and metastatic/recurrent groups were 87.4% and 39.3%, respectively. Inappropriate routes of administration accounted for 25.9% of the chemical uses, attributed to doxorubicin and epirubicin. 100% of chemical uses were dissolved in suitable solvents and solvent volumes as guideline recommendations. Conclusion: Taxan-containing regimens with or without anthracycline are still the most common regimens for breast cancer patients, with the majority of patients being given the recommended doses. The multidisciplinary team needs to keep coordinating to solve some unreasonable problems and optimize treatment effectiveness and safety for patients.