Khảo sát các vấn đề liên quan đến sử dụng kháng sinh tại Khoa Nội tổng hợp - Bệnh viện II Lâm Đồng

Abstract

Objective: To investigate prevalence, types and severity of antibiotic - related problems, and factors related to such problems at a Medical Ward, Lam Dong II General Hospital. Subject and method: A descriptive cross-sectional study on patients treated with antibiotics in the medical ward, from January 1, 2019 to June 30, 2019. DRPs were determined and classified based on the instruction of Pharmaceutical Care Network Europe (2019). The severity of DRP was evaluated by an expert’s panel using Dean & Barber’s approach. DRP related factors were identified using logistic regression model. Result: A total of 335 patients was included in the study (mean age was 69.3 ± 14.6). The majority of patients were male (57.9%). The most common diagnosis was respiratory tract infection (62.4%). Penicillins and fluoroquinolones were the most commonly prescribed antibiotics. About 60% of patients have experienced at least 1 DRP, especially DRP related to antibiotic dosing. The majority of DRPs were considered having moderate clinical relevance. Male patients or patients with creatinine clearance of > 50mL/min were less likely to experience a DRP, whereas patients indicated ≥ 3 antibiotics were more likely to suffer a DRP. Conclusion: Antibiotic-related problems were quite common and mainly due to inappropriate dose. Dose adjustments (according to renal function, especially in patients with creatinine clearance of ≤ 50mL/min) can help improve the appropriateness of antibiotic use.