Bước đầu nghiên cứu nồng độ vitamin D huyết thanh và ảnh hưởng đến kết quả điều trị ở bệnh nhân lao phổi mới AFB(+) tại Bệnh viện 74 Trung ương

Abstract

Objective: Study of serum 25(OH)D₃ levels and effects to results of after 2 months of antituberculosis treatment in new pulmonary tuberculosis patients with AFB(+). Subject and method: 100 new pulmonary tuberculosis patients with AFB(+) at the National Hospital 74 from June to December 2017, consisting of two groups: One with normal 25(OH)D₃ levels (group I) and the other with decreased 25(OH)D₃ levels (group II). Result: Decrease of serum 25(OH)D₃ levels were found in 34% of cases. Before treatment, the proportion of patients with symptoms of dyspnea (38.2%) and the wide lesions (58.8%) in group II were significantly higher than groups I (13.6%, p=0.005; 31.8%, p=0.009). After 2 months of treatment, the rate of patients with weight gain and sputum negative in group I (94.6%; 89.2%) was significantly higher than group II (77.3%; p=0.047 and 63.6%, p=0.018). Rate of patients with nodular injury in group I was significantly lower than before treatment. Serum 25(OH)D₃ levels in patients with wide lesions (21.03 ± 7.36) were significantly lower than those with minimal lesions (25.15 ± 5.49; p=0.036). Conclusion: Decreased serum 25(OH)D₃ levels were seen in 34% of new pulmonary tuberculosis patients with AFB(+). Patients with normal 25(OH)D₃ levels had better results after 2 months of treatment than those with decreased 25(OH)D₃.