ISSN: 1859 - 2872
An observational study on risk factors related to bone mineral density in patients with rheumatoid arthritis
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Abstract
Objective: To investigate some risk factors related to the bone mineral density (BMD) at the lumbar spine and femoral neck in patients with rheumatoid arthritis (RA). Subject and method: A cross-sectional and observational study in 128 inpatients with RA at Bach Mai Hospital. Result: At the lumbar spine, the percentage of patients with osteopenia was 24.2% and that with osteoporosis was 64.8%. At the femoral neck, the former was 48.4% and the latter was 30.5%. Mean BMD of the group with BMI < 18.5 (kg/m2) was lower than that with BMI ≥ 18.5 (kg/m2) (p<0.05). Patients with less than the 2-year duration of the disease had higher BMD at both lumbar spine and femoral neck than those with disease duration of 2 - 5 years or more than 5 years; the later the disease stage was, the more reduction the BMD was (p<0.05). At both lumbar spine and femoral neck, the proportion of osteoporosis of patients with glucocorticoid usage was higher than glucocorticoid naïve ones. Patients with a higher dose of glucocorticoid and longer duration had lower BMD in comparison to those with lose dose and a shorter time of usage (p<0.05). Conclusion: The reduction of bone mineral density related to BMI, disease duration, disease stages, and glucocorticoid usage (including dose and duration of treatment) in patients with rheumatoid arthritis.
Keywords: Rheumatoid arthritis, bone mineral density, glucocorticoid.
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References
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