Levels of peripheral platelet indices in the diagnosis of primary ovarian cancer

  • Vũ Văn Du Bệnh viện Phụ sản Trung ương
  • Nguyễn Thị Phượng Bệnh viện Phụ sản Trung ương
  • Lê Thị Ngọc Hương Bệnh viện Phụ sản Trung ương
  • Lê Thị Trang Bệnh viện Phụ sản Trung ương
  • Đoàn Thị Thanh Xuân Bệnh viện Phụ sản Trung ương
  • Nguyễn Thu Hoài Bệnh viện Phụ sản Trung ương
  • Nguyễn Quang Tùng Viện Huyết học Truyền máu trung ương

Main Article Content

Keywords

PLR, Ovarian cancer, plateletes count

Abstract

Objective: To investigate the change of peripheral platelet indices in ovarian cancer patients and the value of peripheral platelet indices in the diagnosis of primary ovarian cancer. Subject and method: 189 patients with ovarian cancer and 161 patients with benign ovarian tumors were diagnosed by cytology at the National Hospital of Obstetrics and Gynecology. Result: (1) Increased plateletes count, PLR in ovarian cancer group compared with benign ovarian tumor. (2) With cut-off threshold of plateletes count, PLR respectively 262, 126.91 were valuable in the diagnosis of ovarian cancer, with plateletes count > 262G/l, PLR > 126.91 the possibility of ovarian cancer were higher 2.013 and 4.7 times than lower values. Conclusion: Increased plateletes count, PLR in ovarian cancer group compared with benign ovarian tumor. The plateletes count, PLR are prognostic markers in patients with ovarian cancer.

Article Details

References

1. Bakacak M, Serin S, Ercan Ö, Köstü B, Bostancı MS, Bakacak Z, Kıran H, Kıran G (2016) Utility of preoperative neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios to distinguish malignant from benign ovarian masses. J Turk Ger Gynocol Assoc 17(1): 21-25.
2. Kim B, Park Y, Kim B, Ahn HJ, Lee KA, Chung JE, Han SW (2019) Diagnostic performance of CA 125, HE4, and risk of Ovarian Malignancy Algorithm for ovarian cancer. J Clin Lab Anal 33(1): 22624.
3. Yoshida K, Yoshikawa N, Shirakawa A, Niimi K, Suzuki S, Kajiyama H, Kikkawa F (2019) Prognostic value of neutrophil-to-lymphocyte ratio in early-stage ovarian clear-cell carcinoma. J Gynecol Oncol 30(6): 85.
4. Nomelini RS, Carrijo Chiovato AF, Abdulmassih FBF, da Silva RC, Tavares-Murta BM, Murta EFC (2019) Neutrophil-to-lymphocyte ratio and platelet count as prognostic factors in ovarian malignancies. Original article 15(6): 1226-1230.
5. Siegel RL, Miller KD, Jemal A (2015) Cancer statistics. CA Cancer J Clin 65: 5-29.
6. Stone RL, Nick AM, McNeish IA, Balkwill F, Han HD, Bottsford-Miller J (2012) Paraneoplastic thrombocytosis in ovarian cancer. N Engl J Med 366: 610-618.
7. Supoken A, Kleebkaow P, Chumworathayi B, Luanratanakorn S, Kietpeerakool C (2014) Elevated preoperative platelet to lymphocyte ratio associated with decreased survival of women with ovarian clear cell carcinoma. Asian Pac J Cancer Prev 15: 10831-10836.
8. Yildirim MA, Seckin KD, Togrul C, Baser E, Karsli MF, Gungor T, Gulerman HC (2014) Roles of neutrophil/lyphocyte and platelet/lymphocyte ratios in the early diagnosis of malignant ovarian masses. Asian Pac J Cancer Prev 15(16): 6881-6885.
9. Feng Z, Wen H, Bi R, Duan Y, Yang W, Wu X (2016) Thrombocytosis and hyperfibrinogenemia are predictive factors of clinical outcomes in high-grade serous ovarian cancer patients. BMC Cancer 16: 43.

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Published
Nov 1, 2023
DOI: https://doi.org/10.52389/ydls.v18i6.2031
Issue
Volume 18-No 6/2023
Section
Articles
How to Cite
DuV. V., PhượngN. T., HươngL. T. N., TrangL. T., Xuân Đoàn T. T., HoàiN. T., & TùngN. Q. (2023). Levels of peripheral platelet indices in the diagnosis of primary ovarian cancer. Tạp Chí Y Dược lâm sàng 108, 18(6). https://doi.org/10.52389/ydls.v18i6.2031