Đặc điểm lâm sàng, phản ứng huyết thanh và kết quả điều trị ở bệnh nhân giang mai điều trị tại Bệnh viện Da liễu Thành phố Hồ Chí Minh (02/2020-10/2020)

Abstract

Objective: To describe epidermiology, clinical, serology characteristics and management result of syphilis patients with the antibiotic benzathine penicillin at the Ho Chi Minh City Hospital of Dermato-Venereology (February 2020 to October 2020). Subject and method: Descriptive study: Case series. Diagnosis of syphilis is based on a combination of clinical history, physical examination and serologic test results (RPR = Rapid plasma reagin; TPHA = Treponema pallidum haemagglutination test). Eligible participants are all clinical stage of syphilis and untreated patient within the last year. Syphilis patients were treated by guideline of Ho Chi Minh City Hospital of Dermato-Venereology (2019) and follow up the reactions after treatment. Result: 92 patients were included (12 primary, 55 secondary and 25 latent syphilis). The majority of patients were MSM (72.8%), age between 20-29 years old (62%) and single marital status (70%). The main sexual behavior were oral-genital sex (66.3%) and anal intercourse (64.1%). The prevalence of HIV/syphilis co-infection among participants of this study was 32.6%. In secondary syphilis, serum RPR titer between R8-R64 was frequently found (74.5%). The overall incidence of the Jarisch-Herxheimer reaction after treatment was 46.7% and the most symptom was fever (74.4%). The longest time to clear all syphilis clinical findings was 30 days. Conclusion: Our findings suggest that core syphilis patient group currently may be MSM with specific factors. These data are consistent with studies from many countries. Future research should continue to investigate risk factors associated with this core group as well as provide the adequate local syphilis control.