Evaluate TACE efficacy in patients with hepatocellular carcinoma before liver transplantation: Case series reports

  • Nguyễn Lâm Tùng Bệnh viện Trung ương Quân đội 108
  • Nguyễn Tiến Thịnh Bệnh viện Trung ương Quân đội 108
  • Nguyễn Văn Thái Bệnh viện Trung ương Quân đội 108
  • Thái Doãn Kỳ Bệnh viện Trung ương Quân đội 108
  • Mai Thanh Bình Bệnh viện Trung ương Quân đội 108
  • Trần Văn Thanh Bệnh viện Trung ương Quân đội 108
  • Nguyễn Văn Mạnh Bệnh viện Trung ương Quân đội 108
  • Đinh Trường Giang Bệnh viện Trung ương Quân đội 108

Main Article Content

Keywords

Transcatheter arterial chemoembolization (TACE), transplantation, hepatocellular carcinoma, computed tomography scan, histopathology

Abstract

Objective: To evaluate the efficacy of transcatheter arterial chemoembolization (TACE) on computed tomography, histopathological images and AFP in patients with hepatocellular carcinoma before liver transplantation. Subject and method: Retrospective descriptive method, comparing before and after treatment HCC with TACE. Results were evaluated according to mRECIST criteria on CT images and tumor necrosis level on histopathological images. Result: The study included 8 hepatocellular carcinoma patients who were performed TACE before transplantation: Complete response rate was 12.5%, partial response rate was 77.5%, no patients had progressive disease on computed tomography images. Tumor necrosis was greater than 90% in 6 patients (75%) and between 50% and 90% in 2 patients (25%). Conclusion: TACE is initially effective in tumor response on computed tomography and histopathological images.

Article Details

References

1. Yao FY, Ferrell L, Bass NM, Watson JJ, Bacchetti P, Venook A, Ascher NL, Roberts JP (2001) Liver transplantation for hepatocellular carcinoma: expansion of the tumor size limits does not adversely impact survival. Hepatology 33: 1394-1403.
2. Yao FY, Bass NM, Nikolai B et al (2002) Liver transplantation for hepatocellular carcinoma: Analysis of survival according to the intention-to-treat principle and Dropout from the waiting list. Liver Transplantation 8(10): 873-883.
3. Lesurtel M, Müllhaupt B, Pestalozzi BC, Pfammatter T, and Clavien PA (2006) Transarterial chemoembolization as a bridge to liver transplantation for hepatocellular carcinoma: an evidence-based analysis. American Journal of Transplantation 6(11): 2644-2650.
4. Bộ Y tế (2020) Hướng dẫn chẩn đoán và điều trị ung thư biểu mô tế bào gan. Quyết định số 3129/QĐ-BYT-Ngày 17 tháng 7 năm 2020, tr. 12-13.
5. Eisenhauera EA, Therasseb P, Bogaertsc J et al (2009) New response evaluation criteria in solid tumours: Revised RECIST guideline. Eur J Cancer 45(2): 228-247.
6. Alba E, Valls C, Dominguez J, Martinez L, Escalante E, Lladó L, Serrano T (2008) Transcatheter arterial chemoembolization in patients with hepatocellular carcinoma on the waiting list for orthotopic liver transplantation. Amecican Journal of Roentgenology 190: 1341-1348.
7. Antoine Bouchard-Fortier, Real Lapointe et al (2011) Transcatheter arterial chemoembolization of hepatocellular carcinoma as a bridge to liver transplantation: A retrospective study. Int J Hepatol. 2011: 974514.
8. Hołówko W, Wróblewski T, Wojtaszek M, Grąt M, Kobryń K, Ziarkiewicz-Wróblewska B, Krawczyk M (2015) Transarterial chemoembolization prior to liver transplantation in patients with hepatocellular carcinoma. Ann Transplant 20: 764-768.
9. Hameed B, Mehta N, Sapisochin G, Roberts JP, Yao FY (2014) Alpha-fetoprotein level > 1000ng/mL as an exclusion criterion for liver transplantation in patients with hepatocellular carcinoma meeting the Milan criteria. Liver Transpl 20: 945-951.
10. Lao OB, Weissman J, Perkins JD (2009) Pre-transplant therapy for hepatocellular carcinoma is associated with a lower recurrence after liver transplantation. Clin Transplant 23: 874-881.