ISSN: 1859 - 2872
Prognostic role of re-hospitalization and mortality rate of serum sST2 level in patients with chronic heart failure
Main Article Content
Keywords
Abstract
Objective: To investigate the prognostic value of re-hospitalization - mortality of serum sST2 level at the time of hospital admission in patients with chronic heart failure. Subject and method: A total of 116 patients diagnosed as chronic heart failure treated at 103 Military Hospital and 19-8 Hospital were collected from November 2019 to October 2022. Serum sST2 were quantified by ELISA at the time of hospital admission. Information for mortality and re-hospitalization from the patients were collected during a 6-month follow-up period. Result: The rate of re-hospitalization - mortality during the 6-month follow-up period was 37.9%. The area under the curve (AUC) of serum sST2 level in the prognosis of rehospitalization/mortality in the group with EF ≤ 40% was 0.718, p=0.006. In multivariable Cox regression analysis, Log (sST2) (HR = 4.33, p=0.044), Log (NT-proBNP) (HR = 2.90, p=0.011), BMI (HR = 1.4), p=0.004), were prognostic factors in heart failure patients with reduced EF. In univariate Cox regression analysis, sST2 (HR = 2.52, p=0.028), was an independent prognostic factor in heart failure patients with reduced EF. Conclusion: sST2 is a short-term predictor of re-hospitalization/mortality in patients with heart failure with reduced ejection fraction.
Article Details
References
2. Bayes-Genis A, de Antonio M, Vila J, Peñafiel J, Galán A, Barallat J, Zamora E, Urrutia A, Lupón J (2014) Head-to-head comparison of 2 myocardial fibrosis biomarkers for long-term heart failure risk stratification: ST2 versus galectin-3. J Am Coll Cardiol 63(2): 158-166.
3. Yancy CW, Jessup M, Bozkurt B, Butler J, Casey DE Jr, Colvin MM, Drazner MH, Filippatos GS, Fonarow GC, Givertz MM, Hollenberg SM, Lindenfeld J, Masoudi FA, McBride PE, Peterson PN, Stevenson LW, Westlake C (2017) ACC/AHA/HFSA Focused Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America. Circulation 136(6): 137-161.
4. Miller WL, Saenger AK, Grill DE, Slusser JP, Bayes-Genis A, Jaffe AS (2016) Prognostic value of serial measurements of soluble suppression of tumorigenicity 2 and galectin-3 in ambulatory patients with chronic heart failure. J Card Fail 22(4): 249-255.
5. Chăng Thành Chung và Nguyễn Thị Thu Hoài (2021) Nghiên cứu giá trị tiên lượng tử vong và nhập viện của nghiệm pháp đi bộ 6 phút ở bệnh nhân suy tim có phân suất tống máu giảm. Tạp chí Y học Việt Nam, 509, tr. 223-227.
6. Song Y, Li F, Xu Y, Liu Y, Wang Y, Han X, Fan Y, Cao J, Luo J, Sun A, Hu K, Zhou J, Ge J (2020) Prognostic value of sST2 in patients with heart failure with reduced, mid-range and preserved ejection fraction. International Journal of Cardiology 304: 95-100.
7. Aimo A, Januzzi JL Jr, Vergaro G, Richards AM, Lam CSP, Latini R, Anand IS, Cohn JN, Ueland T, Gullestad L, Aukrust P, Brunner-La Rocca HP, Bayes-Genis A, Lupón J, de Boer RA, Takeishi Y, Egstrup M, Gustafsson I, Gaggin HK, Eggers KM, Huber K, Gamble GD, Ling LH, Leong KTG, Yeo PSD, Ong HY, Jaufeerally F, Ng TP, Troughton R, Doughty RN, Passino C, Emdin M (2020) Circulating levels and prognostic value of soluble ST2 in heart failure are less influenced by age than N-terminal pro-B-type natriuretic peptide and high-sensitivity troponin T. Eur J Heart Fail 22(11): 2078-2088.
Article Sidebar
