ISSN: 1859 - 2872
Clinical, subclinical characteristics and risk factors of the new-onset diabetes after transplantation (NODAT) in living donor liver transplantation
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Abstract
Objective: To investigate the characteristics of post-transplantation diabetes melitus and analyze its risk factors. Subject and method: Retrospective and prospective study of 122 patients who underwent living-donor liver transplantation without pre-transplant diabetes from October 2017 to June 2023 at 108 Military Central Hospital. Result: NODAT occurred in 22.9% of liver recipients with a median follow-up time of 19 months. NODAT cases diagnosed within one year after transplantation accounted for 89.2%. Mean age 53.96 ± 10.22 years, 89.2% of patients were male BMI > 25 accounted for 32.2%. The mean HbA1c in NODAT patients was 6.52 ± 0.78%. There was negative correlation between NODAT and patient’s gender, obesity, family history of diabetes. Other factors, such as hepatitis B and C virus infection, cytomegalovirus infection, the number of HLA antigen disparities between donor and recipient, dialysis, plasma exchange or pulse steroid were not found to be associated with the incidence of NODAT. Recipient’s age more than 70, post-transplant intensive care unit stay > 15 days were risk factors for NODAT. Conclusion: Nearly a quarter of the patients had NODAT. The diagnosis and treatment of NODAT plays an important role in the management of patients post-transplantation. More studies are needed to determine the effects of recognition and treatment of hyperglycemia in recent transplant recipients.
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References
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