Đề kháng kháng sinh và điều trị nhiễm khuẩn do Staphylococcus aureus và enterococci tại Bệnh viện Đại học Y Dược thành phố Hồ Chí Minh từ tháng 6/2021 đến tháng 3/2022

Abstract

Objective: Resistance of Staphylococcus aureus and enterococci to antibiotics has increased rapidly worldwide and poses many treatment challenges in selecting the appropriate antimicrobials. This study aims to investigate the antimicrobial resistance of S. aureus and enterococci and the antimicrobial regimens in infection treatment due to these pathogens. Subject and method: A cross-sectional study was conducted on 304 inpatients infected due to at least one of the three pathogens, including S. aureus, E. faecalis, and E. faecium, from 6/2021 to 3/2022 at University Medical Center Ho Chi Minh City. Result: MRSA accounted for 76.3% of S. aureus isolates. 98.2% of S. aureus and 13.5% of E. faecalis isolates were resistant to penicillin, and none of them was resistant to vancomycin or linezolid. The proportions of E. faecium isolates resistant to penicillin G, vancomycin, daptomycin, and linezolid were 84.5%, 40.7%, 98.1%, and 1.8%, respectively. The value of vancomycin MIC and linezolid MIC for most isolates was ≤ 1mg/L and ≤ 2mg/L, respectively. Vancomycin was the most empiric antimicrobial used (45.1%). The combination of two empiric antimicrobials accounted for the highest proportion, with 53.6%. In the group of patients who had to adjust the initial antimicrobial, 58.8% of cases used empiric antimicrobials that were appropriate with these isolates. Conclusion: The high proportions of MRSA and vancomycin-resistant E. faecium were documented in our study. It is necessary to adjust antibiotic regimens using the susceptibility testing results to enhance the appropriateness of antibiotic use