Nồng độ vitamin D huyết thanh ở bệnh nhân viêm da cơ địa

Abstract

Objective: The aim of this study was to examine the correlation between vitamin D concentrations and clinical characteristics of AD in patients. Subject and method: A case-control study was conducted of 60 patients with AD and 30 healthy controls at HCMC Hospital of Dermato - Venereologyfrom October 2014 to May 2015. The diagnosis was based on the Hanifin and Rajka criteria and we evaluated disease severity using the Scoring Atopic Dermatitis (SCORAD) index. Serum vitamin D concentrations were determined by measuring 25-hydroxyvitamin D [25(OH)D] levels using etrochemiluminescence immunoassay (ECLIA). Result: Levels of vitamin D in the control group were higher than in AD (30.52 ± 8.80ng/mL vs 26.37 ± 11.51ng/mL; p=0.08). Our data showed that the ratio of patients with vitamin D deficiency (≤ 20ng/mL) in AD group was 2.75 fold higher than that in control group (36.7% vs 13.3%). Furthermore, vitamin D concentrations in AD group were significantly correlated with the SCORAD index (r = -0.65; p=0.00). Serum vitamin D levels were found to be significantly higher in mild AD (40.91 ± 7.76ng/mL) compared with moderate (28.43 ± 9.82ng/mL) or severe AD (17.21 ± 6.11ng/mL) (p=0.00). Conclusion: This study demonstrated the association between serum vitamin D concentration and AD severity.