Follow up and take care of oral mucositis and lesions of the gastrointestinal disoders in patients treated with hematopoietic stem cell transplantation

  • Phan Văn Phương Bệnh viện Trung ương Quân đội 108
  • Đỗ Thị Lý Bệnh viện Trung ương Quân đội 108
  • Phạm Thanh Huế Bệnh viện Trung ương Quân đội 108
  • Nguyễn Thị Hạnh Dung Bệnh viện Trung ương Quân đội 108
  • Nguyễn Thị Thủy Bệnh viện Trung ương Quân đội 108
  • Phạm Thị Tuyết Nhung Bệnh viện Trung ương Quân đội 108

Main Article Content

Keywords

Gastrointestinal, hematopoietic stem cell transplantation, oral muscositis, cryotherapy.

Abstract

Objective: To determine the rate and extent of injure to the gastrointestinal disoders in patient treated with hematopoietic stem cell transplantation. To evaluate the results of nursing care for these patients. Subject and method: 27 patients at the Center for Hematopoietic Stem cell transplantation at 108 Military Central Hospital from January 2014 to April 2022. Retrospective, cross-sectional descriptive study. Result: 25/27 patients suffered from oral mucositis. 33.3% of patients had most seveer grade 3 mucositis. 100% of patients suffered from nausea and vomiting, of which 33.3% patients had vomiting level 1, 29.6% patients had vomiting level 2 and 37.0% patients were level 3. All of patients had diarrhea, with 14.8% grade 1, 44.4% grade 2, 40.7% grade 3, respectively. Cryotherapy reduced level of mucositis and diarrhea but not influenced nausea and vomiting. Conclusion: Injury of gastrointestinal tract is complication seen in most of stem cell transplant patients. The nursing care is important for the prevention, early detection and mitigation of transplant complications.

Article Details

References

1. Nguyễn Thị Minh Phương và cộng sự (2018) Kết quả ghép tế bào gốc tạo máu tự thân điều trị đa u tủy xương tại Bệnh viện Trung ương Quân đội 108. Tạp chí Y Dược lâm sàng 108, tập 13, tr. 1-8.
2. Wallhult E and Quinn B (2018) Early and acute complications and the principles of HSCT nursing care. The European blood and marrow transplantation textbook for nurses: 163-168.
3. Atilla E, Ataca Atilla P, Cengiz Seval G, Bektaş M, Demirer T (2018) Current approach to early gastrointestinal and liver complications of hematopoietic stem cell transplantation. Turk J gastroenterol 30(2): 122-131.
4. Granzziutti ML et al (2006) Oral mucositis in myeloma patients undergoing melphalan-based autologous stem cell transplantation: Incidence, risk factors and a severity predictive model. Bone marrow transplantation 38: 501-506.
5. Cunha R (2018) Diarrhea after autologous stem cell transplantation in low-middle income countries: Is Clostridium difficile the most prevalent infectious etiology? Hematology, transfusion and cell therapy 40(2): 105-106.
6. Vanleh M, Kargar M, Mansouri A, Kamranzadeh H, Gholami K, Heidari K, Hajibabaei M (2018) Factors affecting the incidence and severity of oral mucositis following hematopoietic stem cell transplantation. International journal of Hematology-Oncology and Stem cell reseach 12(2): 142-152.
7. Giorgi UD, Wandt H, Lioure B et al (2004) First-line high-dose chemotherapy for patients with poor prognosis extragonadal germ cell tumors. The experience of the European Bone Marrow Transplantation (EBMT) Solid Tumors Working party. Bone Marrow Transplant 34: 1033-1037.
8. Tuncer H, Rana N, Milani C et al (2012) Gastrointestinal and hepatic complications of hematopoietic stem cell transplantation. World J Gastroenterol 18: 1851-1860.