Tình hình kháng kháng sinh của các chủng vi khuẩn gây nhiễm khuẩn tiết niệu tại Bệnh viện Đa khoa Quốc tế Thu Cúc giai đoạn 2018 - 2019

Abstract

Objective: To identify antibiotic resistance rate of common pathogenic bacteria causing urinary tract infections (UTIs) at Thu Cuc International General Hospital from 2018 to 2019. Subject and method: 190 strains isolated from 695 urine samples of patients who treated at Thu Cuc International General Hospital from January 2018 to December 2019. Method: To culture for quantifying the number of bacteria in 1ml of urine and to identify bacteria by kit of biological and chemical characters API. Result: 27.33% specimen samples with positive culture; the common pathogenic bacteria in urinary tract infections were: E. coli (41.58%), S. epidermidis (21.58%), S. saprophyticus (20.53%), Entorococcus spp. (8.42%, and Klebsiella spp. (5.79%). E. coli was resistance to quinolones (levofloxacin: 38.9%, ciprofloxacin: 40.3%), sensitive to the third and fourth generation cephalosporin (ceftriaxon: 58.6%, ceftazidim: 70% and cefepim: 77.1%), amikacin (70.7%), imipenem (89.4%) and meropenem (92.6%); S. epidermidis was resistance to the second and third generation cephalosporins (cefuroxim: 37.9%, ceftriaxon: 43.3% and ceftazidim: 53.8%),  sulfamethoxazole/trimethoprim (95%) and quinolon (resistance to levofloxacin, ofloxacin and ciprofloxacin were 36.7%, 61.8% and 67.6%, respectively); sensitive to the β-lactam/β-lactamase inhibitor combinations, imipenem (97%) and meropenem (89.3%). S. saprophyticus was resistance to the second and third generation cephalosporin (cefuroxim: 30.3%, ceftriaxon: 43.2% and ceftazidim: 66.7%), sulfamethoxazole/trimethoprim (69%) and quinolon (resistance to levofloxacin, ofloxacin and ciprofloxacin were 43.5%, 59.3% and 58.1%, respectively), sensitive to the β-lactam/β-lactamase inhibitor combinations, imipenem (90%) and meropenem (95.7%). Enterococcus spp. was resistance to the second and third generation cephalosporins (cefuroxim: 80%, ceftriaxon: 57.1% and ceftazidim: 63.6%)), quinolons (resistance to levofloxacin, ciprofloxacin and ofloxacin were 38.5%, 50% and 50%, respectively), resistance to aminosid (amikacin: 25% and gentamycin: 37.5%) and oxacillin (100%), reduced sensitivity to carbapenem (imipenem: 92.9% and meropenem: 62.5%), sensitive to vancomycin (83.3%). Conclusion: The common pathogenic bacteria for UTIs isolated at Thu Cuc International General Hospital were: E. coli (41.58%), S. epidermidis (21.58%), S. saprophyticus (20.53%) Entorococcus spp. (8.42%), and Klebsiella spp., (5.79%), all of them were resitance to the penicillin, the first generation cephalosporin; intermidiate resistance to the second and third generation cephalosporin (exclude E. coli), quinolon; high sensitive to carbapenem. Requiring a good management of antibiotic use.