Efficacy and safety of Diquas in patients after LASIK surgery

  • Hiep Nguyen Xuan Bệnh viện Mắt Trung ương
  • Khanh Pham Thi Minh Bệnh viện Mắt Trung ương

Main Article Content

Keywords

Diquas, LASIK, dry eye

Abstract

Objective: To evaluate the efficacy and safety of Diquas in patients after LASIK surgery. Subject and method: Prospective non comparative trial. Fifty eyes of 25 patients after LASIK. Assessed TBUT, schirmer I, fluorescein, rose bengal staining score and the subjective symptoms (foreign body sensation, eye pain, dry feeling, feeling of burning, fatigue of the eyes, blurred vision, lacrimation) before and after treatment with diquas 1 month, 2 months and 3 months. Recorded the symptoms of adverse reactions (red eye, swelling of the conjunctiva or eyelid, pain eye, blurred vision, headache…). Result: At the 1 month, 2 months and 3 months after treatment with Diquas: TBUT, schirmer I increased significantly in eyes after LASIK, fluorescein and rose bengal staining score decreased significantly with p<0.01. The subjective symptoms (foreign body sensation, eye pain, dry feeling, feeling of burning, fatigue of the eyes, blurred vision) were improved as well (p<0.01). Six eyes after LASIK were red and pain itching after treatment 1 week. Conclusion: Diquas has the efficacy and safety in patients after LASIK surgery.

Article Details

References

1. Akihiko Y, Kazuo T, Yuichi O (2012) An open label long-term study of 3% diquafosol sodium in dry eyes. Journal of the Eye 29: 527-535.
2. Ayami M, Yosai M, Ryohei N et al (2013) Efficacy of long-term treatment with diquafosol sodium for dry eye due to laser in situ keratomileusis. Journal of the Eye 30(2): 249-253.
3. Corrales RM, Narayanan S, Fernandez I et al (2011) Ocular mucin gene expression levels as biomarkers for the diagnosis of dry eye syndrome. Invest Ophthalmol Vis Sci 52: 8363-8369.
4. Erie JC, McLaren JW, Hodge DO, Bourne WM (2005) Recovery of corneal subbasal nerve density after PRK and LASIK. Am. J. Ophthalmol 140: 1059–1064.
5. Kamiya K, Nakanishi M et al (2012) Clinical evaluation of the additive effect of diquafosol tetrasodium on sodium hyaluronate monotherapy in patients with dry eye syndrome: A prospective, randomized, multicenter study. Eye 26: 1363-1368.
6. Marcella Q Salomão et al (2009) Dry eye associated with laser in situ keratomileusis: Mechanical microkeratome versus femtosecond laser. J Cataract Refract Surg 35(10): 1756-1760.
7. Patel SV, Mclaren JW, Kittleson KM et al (2010) Subbasal nerve density and corneal sensitivity after laser in situ keratomileusis: Femtosecond laser vs mechanical microkeratome. Arch Ophthalmol 128: 1413-1419.
8. Tauber J, Davitt WF, Bokosky JE et al (2004) Double-masked, placebo-controlled safety and efficacy trial of diquafosol tetrasodium (INS365) ophthalmic solution for the treatment of dry eye. Cornea 23: 784-792.
9. Toda I, Asano-Kano N, Komai-Hori Y et al (2001) Dry eye after laser in situ keratomileusis. Am J Ophthalmol 132: 1-7.
10. Toda I, Ide T, Fukumoto T, Ichihashi Y, Tsubota K (2014) Combination therapy with diquafosol tetrasodium and sodium hyaluronate in patients with dry eye after laser in situ keratomileusis. Am J Ophthalmol 157(3): 616-622.