Giá trị của chỉ số easix trong tiên lượng mức độ nặng và suy tạng ở bệnh nhân viêm tụy cấp

Abstract

Objective: To evaluate the value of the Endothelial Activation and Stress Index (EASIX) in predicting severity and organ failure in acute pancreatitis patients. Subject and method: A prospective, longitudinal, descriptive study was conducted on 121 patients diagnosed with acute pancreatitis according to the revised Atlanta 2012 criteria, treated at Military Central Hospital 108 and Military Hospital 103 from June 2025 to May 2026. The EASIX index was calculated using the formula LDH × Creatinine/Platelet count from the first laboratory test within 24 hours of admission. Organ failure was defined as a SOFA score ≥ 2. The prognostic value of EASIX was assessed by the area under the ROC curve (AUROC), with optimal cut-off determined by the Youden index. Result: Edematous acute pancreatitis accounted for 82.6% and the necrotizing type for 17.4%. The rate of severe acute pancreatitis was 15.7% and the rate of organ failure was 19%, of which single organ failure accounted for 65.2% and multi-organ failure (≥ 2 organs) for 34.8%. The EASIX index demonstrated good prognostic value for severe acute pancreatitis, with an AUROC of 0.802 (95% CI: 0.68 - 0.92; p<0.001). At a cut-off of 1.5, the sensitivity was 78.9% and the specificity was 80.4%. For predicting organ failure, EASIX achieved an AUROC of 0.79 (95% CI: 0.68 - 0.90; p<0.001); at a cut-off of 1.21, sensitivity was 82.6% and specificity was 72.4%. For predicting pancreatic necrosis, EASIX had an AUROC of 0.735 (95% CI: 0.62–0.85; p = 0.001) at a cut-off of 1.13. Conclusion: The EASIX index is a simple, feasible and valuable prognostic tool for predicting severity and organ failure in patients with acute pancreatitis, applicable within the first 24 hours of admission for early risk stratification